Results 61 to 70 of about 10,420,356 (335)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Stabilization of the retinal vascular network by reciprocal feedback between blood vessels and astrocytes [PDF]

, 2005
Development of the retinal vasculature is controlled by a hierarchy of interactions among retinal neurons, astrocytes and blood vessels. Retinal neurons release platelet-derived growth factor (PDGFA) to stimulate proliferation of astrocytes, which in ...
Heloise West, Richardson, WD, West, H, William D. Richardson, Fruttiger, M, Marcus Fruttiger   +5 more
core   +1 more source

Factors of angiogenesis in the development of physiological and pathological processes of the female gonads

Бюллетень сибирской медицины, 2016
The literature review focuses on the role of various growth factors in the developing vasculature of the ovary. Vascularization plays an important role in physiological processes such as development and atresia of a follicle, the formation of the yellow ...
V. G. Zenkina
doaj   +1 more source

Abl family kinases regulate endothelial barrier function in vitro and in mice. [PDF]

PLoS ONE, 2013
The maintenance of endothelial barrier function is essential for normal physiology, and increased vascular permeability is a feature of a wide variety of pathological conditions, leading to complications including edema and tissue damage.
Elizabeth M Chislock, Ann Marie Pendergast   +1 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Vascular endothelial growth factor and its receptors in male fertility

, 1999
Objective: To determine the concentration of vascular endothelial growth factor in the seminal fluid, the presence of vascular endothelial growth factor receptors Flt-1 and KDR in spermatozoa, and the predictive value of seminal vascular endothelial ...
Andreas Obruca, Obruca, A, Andreas Obermair, Leodolter, S, Obermair, A, Vales, A, Pohl, M, Johann Wojta, Michaela Pöhl, Feichtinger, W, Sepp Leodolter, Alexandra Kaider, Anja Vales, Kaider, A, Wojta, J, Wilfried Feichtinger   +15 more
core   +1 more source

Circulating humoral factors and endothelial progenitor cells in patients with differing coronary collateral support [PDF]

, 2004
Background - The mechanisms underlying the variation in collateral formation between patients, even with similar patterns of coronary artery disease, remain unclear.
Bucknall, CA, Meng, Y G, Redwood, SR, Pearson, JD, Redwood, S R, Edwards, R J, Lambiase, PD, Marber, MS, Edwards, RJ, Anthopoulos, P, Rahman, S, Lambiase, P D, Meng, YG, Pearson, J D, Marber, M S; id_orcid, Bucknall, C A   +15 more
core   +1 more source

Characterization of Novel Vascular Endothelial Growth Factor (VEGF) Receptors on Tumor Cells That Bind VEGF via Its Exon 7-encoded Domain (*)

Journal of Biological Chemistry, 1996
Vascular endothelial growth factor (VEGF), a potent angiogenic factor, uses two receptor tyrosine kinases, FLK/KDR and FLT, to mediate its activities. We have cross-linked I-VEGF to the cell surface of various tumor cell lines and of human umbilical vein
S. Soker, H. Fidder, G. Neufeld, M. Klagsbrun   +3 more
semanticscholar   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Vascular endothelial cells and angiogenesis

Pharmacological Research
Physiological vascular endothelial cell division and angiogenesis occur during embryonic development, wound healing, in the endometrium during the menstrual cycle, and during placental development.
Robert Roskoski, Jr.
doaj   +1 more source