Results 101 to 110 of about 399,510 (314)

Defective interfering particles of parainfluenza virus subtype 5 and interferon induction

, 2015
The innate immune response is the first line of defence against virus infection. Cells contain a diverse array of pathogen recognition receptors (PRRs) that are able to recognise multiple pathogen associated molecular patterns (PAMPS) that present ...
Short, John A. L.
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Differential contribution of PB1-F2 to the virulence of highly pathogenic H5N1 influenza A virus in mammalian and avian species [PDF]

, 2011
Highly pathogenic avian influenza A viruses (HPAIV) of the H5N1 subtype occasionally transmit from birds to humans and can cause severe systemic infections in both hosts.
García-Sastre, Adolfo, García-Sastre, A., Rong Hai, Hale Benjamin G., Pena, Lindomar, Hai, Rong, John Steel, Manicassamy Balaji, Daniel R. Pérez, Pérez Daniel R., Manicassamy, Balaji, Pena, L., Benjamin G. Hale, Sutton, T., Zsuzsanna T Varga, Troy Sutton, Sutton Troy, Varga Zsuzsanna T., Hale, B.G., Varga, Zsuzsanna T, Pena Lindomar, Zsuzsanna T. Varga, Hale, Benjamin G, Balaji Manicassamy, Adolfo García-Sastre, Schmolke, M., Hai Rong, Hai, R., Daniel R Pérez, Pérez, D.R., Sutton, Troy, Steel, John, Pérez, Daniel R, Steel, J., Steel John, García-Sastre Adolfo, Manicassamy, B., Mirco Schmolke, Lindomar Pena, Benjamin G Hale, Schmolke, Mirco, Varga, Z.T., Schmolke Mirco   +42 more
core   +1 more source

Influenza Infection in Wild Raccoons

Emerging Infectious Diseases, 2008
Raccoons (Procyon lotor) are common, widely distributed animals that frequently come into contact with wild waterfowl, agricultural operations, and humans. Serosurveys showed that raccoons are exposed to avian influenza virus.
Jeffrey S. Hall, Kevin T. Bentler, Gabrielle Landolt, Stacey A. Elmore, Richard B. Minnis, Tyler A. Campbell, Scott C. Barras, J. Jeffrey Root, John Pilon, Kristy Pabilonia, Cindy Driscoll, Dennis Slate, Heather Sullivan, Robert G. McLean   +13 more
doaj   +1 more source

The virus–receptor interaction in the replication of feline immunodeficiency virus (FIV)

Current Opinion in Virology, 2013
The feline and human immunodeficiency viruses (FIV and HIV) target helper T cells selectively, and in doing so they induce a profound immune dysfunction. The primary determinant of HIV cell tropism is the expression pattern of the primary viral receptor CD4 and co-receptor(s), such as CXCR4 and CCR5.
Willett, Brian J, Hosie, Margaret J
openaire   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Measles Virus Receptor SLAM (CD150)

Virology, 2002
Measles virus (MV), a member of the Morbillivirus genus in the Paramyxoviridae family, is an enveloped virus with a nonsegmented negative-strand RNA genome and infects humans and nonhuman primates (Griffin, 2001). Despite the availability of vaccines, MV remains a major cause of childhood mortality, claiming roughly one million lives a year worldwide ...
Yanagi, Yusuke, Ono, Nobuyuki, Tatsuo, Hironobu, Hashimoto, Koji, Minagawa, Hiroko   +4 more
openaire   +2 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Antigenic drift in H5N1 avian influenza virus in poultry is driven by mutations in major antigenic sites of the hemagglutinin molecule analogous to those for human influenza virus [PDF]

, 2011
H5N1 highly pathogenic avian influenza virus has been endemic in poultry in Egypt since 2008, notwithstanding the implementation of mass vaccination and culling of infected birds.
Arafa, Abdel, Temperton, Nigel J., Giovanni Cattoli, Alessandra Buratin, Mona Meherez Aly, Adelaide Milani, Cattoli, Giovanni, Milani, Adelaide, Zecchin, Bianca, Ilaria Capua, Capua, Ilaria, Eleonora Molesti, Bianca Zecchin, Abdel Arafa, Buratin, Alessandra, Aly, Mona Meherez, Temperton, Nigel, Meherez Aly, Mona, Nigel Temperton, Molesti, Eleonora   +19 more
core   +1 more source