Results 131 to 140 of about 4,110,019 (315)
Journal of Virology, 2010 Although sialic acid has long been recognized as the primary receptor determinant for attachment of influenza virus to host cells, the specific receptor molecules that mediate viral entry are not known for any cell type.
Jacqueline P. Upham +4 more
semanticscholar +1 more source
Hydrogen sulfide repairs testicular damage induced by heat stress in rats
FEBS Open Bio, EarlyView.Heat stress can cause testicular damage and affect fertility. We investigated the potential protective role of hydrogen sulfide (H2S) against heat stress‐induced testicular injury and observed that H2S donor NaHS can effectively restore testicular damage in rats by inhibiting inflammation and oxidative stress. Our results suggest that H2S might be used
Xinyu Guo +6 more
wiley +1 more source
Spike conformation transition in SARS-CoV-2 infection [PDF]
arXiv, 2020 A theory on the conformation transition for SARS-CoV-2 spike protein (S) is proposed. The conformation equilibrium between open (up) and closed (down) conformations of receptor binding domain (RBD) of the spike is studied from the first-principle. The conformational state population is deduced from the free energy change in conformation transition of S
arxiv
Journal of Immunology, 2010 Elevated expression of inhibitory receptors on virus-specific T cells has been implicated as a mechanism by which viruses evade host immune surveillance.
A. Kassu +8 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.Heterologous expression of membrane transporters in cultured cells is essential for functional characterization, but is sometimes limited by low activity. Our study compares the HDAC inhibitors butyrate, VPA and SAHA to enhance transport activity. We propose to replace butyrate by SAHA: it is equally effective, devoid of repulsive odor, costs less, and
Svenja Flögel +4 more
wiley +1 more source
TAM Receptors Are Not Required for Zika Virus Infection in Mice
Cell Reports, 2017 Summary: Tyro3, Axl, and Mertk (TAM) receptors are candidate entry receptors for infection with the Zika virus (ZIKV), an emerging flavivirus of global public health concern.
Andrew K. Hastings +12 more
doaj
Hepatitis C Virus Evasion from RIG-I-Dependent Hepatic Innate Immunity
Gastroenterology Research and Practice, 2010 Exposure to hepatitis C virus (HCV) usually results in persistent infection that often develops into chronic liver disease. Interferon-alpha (IFN) treatment comprises the foundation of current approved therapy for chronic HCV infection but is limited in ...
Helene Minyi Liu, Michael Gale
doaj +1 more source
Molecular Communication Theoretical Modeling and Analysis of SARS-CoV2 Transmission in Human Respiratory System [PDF]
arXiv, 2020 Severe Acute Respiratory Syndrome-CoronaVirus 2 (SARS-CoV2) caused the ongoing pandemic. This pandemic devastated the world by killing more than a million people, as of October 2020. It is imperative to understand the transmission dynamics of SARS-CoV2 so that novel and interdisciplinary prevention, diagnostic, and therapeutic techniques could be ...
arxiv
PLoS Pathogens, 2017 Cell entry of many enveloped viruses occurs by engagement with cellular receptors, followed by internalization into endocytic compartments and pH-induced membrane fusion.
H. Israeli +4 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui +15 more
wiley +1 more source