Results 161 to 170 of about 4,110,019 (315)

Evolution of H7N9 highly pathogenic avian influenza virus in the context of vaccination

Emerging Microbes and Infections
Human infections with the H7N9 influenza virus have been eliminated in China through vaccination of poultry; however, the H7N9 virus has not yet been eradicated from poultry.
Yujie Hou, Guohua Deng, Pengfei Cui, Xianying Zeng, Bin Li, Dongxue Wang, Xinwen He, Cheng Yan, Yaping Zhang, Jiongjie Li, Jinming Ma, Yanbing Li, Xiurong Wang, Guobin Tian, Huihui Kong, Lijie Tang, Yasuo Suzuki, Jianzhong Shi, Hualan Chen   +18 more
doaj   +1 more source

ADAPT NXT: Fixed Cycles or Every‐Other‐Week IV Efgartigimod in Generalized Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This phase 3b, open‐label, randomized ADAPT NXT study investigated the efficacy, safety, and tolerability of efgartigimod administered in either a fixed cycles dosing regimen (3 cycles of 4 once‐weekly infusions, with 4 weeks between cycles) or a cycle followed by every‐other‐week (Q2W) dosing.
Ali A. Habib, Kristl G. Claeys, Vera Bril, Yessar Hussain, Kelly Gwathmey, Gregory Sahagian, Elena Cortés‐Vicente, Edward Brauer, Deborah Gelinas, Anne Sumbul, Rosa H. Jimenez, Daniela Hristova, Delphine Masschaele, Renato Mantegazza, Andreas Meisel, Shahram Attarian, On behalf of the ADAPT NXT Study Group   +16 more
wiley   +1 more source

Progress and challenges in development of animal models for dengue virus infection

Emerging Microbes and Infections
The severity of the dengue epidemic is on the rise, with its geographic range had expanded to southern Europe by 2024. In this August, the WHO updated the pathogens that could spark the next pandemic, dengue virus was on the list.
Wang Yuya, Yang Yuansong, Liu Susu, Ling Chen, Wu Yong, Wang Yining, Wang YouChun, Fan Changfa   +7 more
doaj   +1 more source

Spatiotemporal Control Over Protein Release from Artificial Cells via a Light‐Activatable Protease

Advanced Biology, EarlyView.
Stimulus‐responsive protein release is essential for intercellular communication. Mimicking this functionality in artificial cells is promising to study the working principles of cellular signaling. Herein, an engineered light‐activatable protease is implemented in a coacervate‐based artificial cell platform to establish user‐defined spatiotemporal ...
Arjan Hazegh Nikroo, Wiggert J. Altenburg, Thijs W. van Veldhuisen, Luc Brunsveld, Jan C. M. van Hest   +4 more
wiley   +1 more source

Light‐Triggered Protease‐Mediated Release of Actin‐Bound Cargo from Synthetic Cells

Advanced Biology, EarlyView.
TEV Prtoease‐mediated Releasable Actin‐binding Protein (TRAP) is a protein‐based platform consisting of a cargo tightly bound to reconstituted actin networks in synthetic cells which can be proteolyticly released from the bound actin, followed by its secretion through membrane translocation mediated by a cell‐penetrating peptide.
Mousumi Akter, Hossein Moghimianavval, Gary D. Luker, Allen P. Liu   +3 more
wiley   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

The Regulation of Trace Metal Elements in Cancer Ferroptosis

Advanced Biology, EarlyView.
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang, Yuanyuan Xue, Lei Chang, Xuena Zhu, Wenjun Liu, Tingbo Liang   +5 more
wiley   +1 more source

Consolidate Overview of Ribonucleic Acid Molecular Dynamics: From Molecular Movements to Material Innovations

Advanced Engineering Materials, EarlyView.
Molecular dynamics simulations are advancing the study of ribonucleic acid (RNA) and RNA‐conjugated molecules. These developments include improvements in force fields, long‐timescale dynamics, and coarse‐grained models, addressing limitations and refining methods.
Kanchan Yadav, Iksoo Jang, Jong Bum Lee
wiley   +1 more source

Amplification‐Free, Sequencing‐Free, Detection of Viral RNAs with Variant Specification by Discrete Nanocounting

Advanced Functional Materials, EarlyView.
Integrating selective RNA shortcut, targeted gene isolation, and micro‐arrayed nanoimaging, the NanoPick‐array platform excels in detecting severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) at just 60 copies µL−1 and accurately differentiating variants at the single‐nucleotide level. It ensures 100% accuracy for samples with cycle threshold (
Zixun Wang, Xi Zhao, Wan‐Mui Chan, Xianglin Ji, Linfeng Huang, Xi Xie, Wei Li, Wenjun Zhang, Kelvin Kai‐Wang To, Peng Shi   +9 more
wiley   +1 more source

Research progress on the pattern recognition receptors involved in porcine reproductive and respiratory syndrome virus infection

Frontiers in Cellular and Infection Microbiology
Porcine reproductive and respiratory syndrome (PRRS) is one of the most economically devastating infectious diseases of pigs globally. The pathogen, porcine reproductive and respiratory syndrome virus (PRRSV), is an enveloped positive-stranded RNA virus,
Yulin Xu, Yulin Xu, Luogang Ding, Luogang Ding, Yuyu Zhang, Yuyu Zhang, Sufang Ren, Sufang Ren, Jianda Li, Jianda Li, Fei Liu, Fei Liu, Wenbo Sun, Wenbo Sun, Zhi Chen, Zhi Chen, Jiang Yu, Jiang Yu, Jiaqiang Wu, Jiaqiang Wu   +19 more
doaj   +1 more source