Results 161 to 170 of about 4,142,916 (290)
Lipid Nanoparticle‐Mediated CRISPR‐Cas13a Delivery for the Control of Bacterial Infection
Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.New formulations of lipid nanoparticles (LNPs) that can deliver nucleic acids to Gram‐negative bacteria are proposed to combat bacterial infection. The delivery of nucleic acids by LNPs is aided by LNP‐helpers which weaken the bacterial outer membrane. LNPs encapsulating the Cas13a/gRNA expression vector achieve an antibacterial effect in both in vivo ...
Bookun Kim +9 more
wiley +1 more source
Single Amino Acid Residue W33 of <i>tva</i> Receptor Is Critical for Viral Entry and High-Affinity Binding of Avian Leukosis Virus Subgroup K. [PDF]
VirusesGáliková E +5 more
europepmc +1 more source
Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.The top‐performing lipid nanoparticle, incorporating a novel ionizable lipid derived from vitamin B5, demonstrates high mRNA transfection efficiency, low toxicity, favorable stability, targeted delivery to lymphoid tissues, and high immunogenicity, showing promise as a carrier for mRNA vaccines for infectious diseases and cancer.
Soyeon Yoo +11 more
wiley +1 more source
HSV1 glycoprotein D utilizes an LY6-like binding domain to inhibit alpha7 nicotinic receptors. [PDF]
Npj VirusesYeasmin S +8 more
europepmc +1 more source
Innate immunity to influenza virus infection
Nature reviews. Immunology, 2014 A. Iwasaki, Padmini S. Pillai
semanticscholar +1 more source
Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.Islatravir‐loaded dissolving microarray patches (MAPs) provide a minimally invasive, long‐acting solution for HIV‐1 prevention and treatment. In rats, sustained islatravir delivery lasts up to three months, while in minipigs, efficacious plasma levels are detected for six days.
Qonita Kurnia Anjani +11 more
wiley +1 more source
The Evolving Role of Zika Virus Envelope Protein in Viral Entry and Pathogenesis. [PDF]
VirusesRoozitalab A +4 more
europepmc +1 more source
Advanced Healthcare Materials, EarlyView.This perspective provides an overview of the growing interest in utilizing various gasotransmitters—small gaseous signaling molecules namely nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)—for several therapeutic applications, with emphasis on the potential use of porous materials as carriers to provide safe and controlled local ...
Rosana V. Pinto +2 more
wiley +1 more source
Autophagy-mediated downregulation of AXL and TIM-1 promotes sustained Zika virus infection. [PDF]
Proc Natl Acad Sci U S AYu J +6 more
europepmc +1 more source
Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy
Advanced Healthcare Materials, EarlyView.The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq +4 more
wiley +1 more source