Results 241 to 250 of about 609,928 (307)

Chronobiology of neurotropic viruses: rhythmic viral entry and arrhythmic host clocks. [PDF]

Cell Discov
Zeng S, Zhang Q, Yang X, Lv L, Zhang Y, Zhang Z, Wang Q, Luo MH, Dorf M, Li S, Zhao L, Fu B.   +11 more
europepmc   +1 more source

Timing Mechanotransduction: Mechanically Dynamic Biomaterials Reveal the Temporal Hierarchy of YAP/TAZ Control Nodes

Advanced Science, EarlyView.
This work develops dynamically softening polyacrylamide hydrogels for time‐resolved imaging during continuous mechanical transitions. The study revealed that mechanotransduction is biphasic; YAP/TAZ inactivation is driven by early loss of the nucleocytoskeletal continuum connecting subnuclear adhesions, F‐actin, and the nuclear envelope, coupled with ...
Alessandro Gandin, Giada Vanni, Veronica Torresan, Margherita Pelosin, Rebecca Busetto, Anna Citron, Ambela Suli, Paolo Contessotto, Carlo Albanese, Francesca Zanconato, Tito Panciera, Stefano Piccolo, Giovanna Brusatin   +12 more
wiley   +1 more source

Mitochondrial quality control: a new mechanism for antiviral therapy. [PDF]

Front Immunol
Duan X, Lan W, Liu R, Zhang P, Chen S, Zhang Y, Zhang L, Li H, Liu S.   +8 more
europepmc   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Primary bovine embryonic fibroblasts demonstrate variable fitness following infection with highly pathogenic avian influenza H5N1 strains and are susceptible to a recently circulating human 2009 pandemic lineage H1N1 strain. [PDF]

Microbiol Spectr
Wenger GK, Snyder DT, Prigge JR, Turner AH, Jaffrani SA, Schmidt EE, Bruce EA, Loveday EK.   +7 more
europepmc   +1 more source

Decoding Triphenotypic Neutrophils in Cervical Cancer Evolution and Targeting SPP1+/GBP1+/ELOVL5+ Tumor‐Associated Neutrophils to Sensitize Immunotherapy

Advanced Science, EarlyView.
The functional schematic diagram of tumor associated neutrophils. Abstract Enhancing cervical cancer (CC) immunotherapy requires deciphering the heterogeneous tumor immune microenvironment (TIME), particularly neutrophil phenotypic dynamics. Here, 1) we collected 543 CC cases to find that patients with elevated neutrophil levels have a higher incidence
Xingyu Chang, Xinyu Qu, Tingting Ren, Tong Wu, Weiyong Gu, Jingxin Ding, Keqin Hua, Junjun Qiu   +7 more
wiley   +1 more source

Enterovirus D68 receptor usage: from static attachment to dynamic entry. [PDF]

J Virol
Liu D, Ji Z, Zheng X, Xia H, Yang W, Ge P-F, Wei W.   +6 more
europepmc   +1 more source

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, EarlyView.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

The contributions of TLR2, TLR8 and TLR3 to direct and antibody-dependent enhancement of dengue virus serotype 2 infection. [PDF]

Npj Viruses
Ter Ellen BM, Punekar M, Castillo JA, Valdés-López JF, Upasani V, Sann S, Karnthaler M, Martija B, Moser J, Smit JM, Cantaert T, Rodenhuis-Zybert IA.   +11 more
europepmc   +1 more source