Results 51 to 60 of about 71,476 (291)

ECONOMIC POLICY TO OVERCOME STAGNATION AFTER THE FINANCIAL CRISIS

open access: yesВестник университета, 2021
The article considers the downward spiral of deflation, its causes and consequences. The paper discusses the compression of aggregate demand and the subsequent recession.
V. D. Kuligin
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

An Artificial Neural Network for Prediction of Front Slope Recession in Berm Breakwater

open access: yesInternational Journal of Coastal and Offshore Engineering, 2018
Berm breakwaters are used as protective structures against the wave attack where larger quarry materials as armor stone is scarce, or large quarry materials are available but using berm breakwater lowers the costs considerably.
Alireza Sadat Hosseini   +2 more
doaj  

Extra Ocular Muscle Fenestration as a Weakening Maneuver for Surgical Management of Strabismus: A Randomized Pilot Clinical Trial

open access: yesClinical Ophthalmology, 2022
Sameh G Taher,1 Mahmoud A Rageh,1 Omar Hashem2 1Department of Pediatric Ophthalmology and Strabismus, Research Institute of Ophthalmology, Giza, Egypt; 2Department of Cornea and Refractive Surgery, Research Institute of Ophthalmology, Giza ...
Taher SG, Rageh MA, Hashem O
doaj  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Modified Faden operation –A new surgical technique

open access: yesIndian Journal of Ophthalmology, 2019
Faden operation was first described in 1912. It weakens the muscle in its field of action without much slackening and alteration in the primary position. When combined with recession the weakening effect is more.
Manjula Jayakumar   +2 more
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

open access: yesMolecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken   +3 more
wiley   +1 more source

Double-sided balanced conditional Sharpe ratio

open access: yesCogent Economics & Finance, 2019
The purpose of this study was to investigate the behavior of various indices of Tehran Stock Exchange firstly in the boom period from 2018-03-21 to 2018-11-02 and secondly in the recession period from 2016-03-20 to 2016-12-20 using double-sided balanced ...
Saeid Tajdini   +2 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Inflation Analysis and Impact on the Business Environment in Romania [PDF]

open access: yesOvidius University Annals: Economic Sciences Series
This research deals with aspects related to the state of recession marked by the effects of inflation, thus analyzing how the business environment in Romania is affected, presenting statistical data from the period 2023 - 2024 regarding the number of ...
Marius Dan Bența   +2 more
doaj  

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