Results 71 to 80 of about 5,177,735 (339)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
LE CHOIX ET LA PERTINENCE D’UNE APPROCHE DE RECHERCHE MIXTE STRATÉGIQUE ET COMPARATIVE DANS UNE RECHERCHE EN SCIENCES POLITIQUES ET ADMINISTRATIVES [PDF]
Cahiers Africains des Droits de l’Homme et de la Démocratie ainsi que du Développement Durable, 2022 Cette réflexion est une contingence relative à la thèse de doctorat de l’auteur, intitulée « Elections présidentielles dans les Etats post-conflits et les contestations des résultats en Afrique subsaharienne.
Germain MUBENGA NGELEKA
doaj
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
Le volontarisme agricole et coopératif : un moteur d’innovation. L’exemple du chanvre industriel
Oilseeds and fats, crops and lipids, 2013 Le chanvre industriel moderne (20e et 21e siècle) est une filière de taille très petite. Le nombre d’acteurs est très restreint et ils sont aisément identifiables.
Bertucelli Sylvestre
doaj +1 more source
Répertoire thématique des rapports finals de recherche et des projets en cours--
, 1981 1980 /Comprend des ...
Conseil québécois de la recherche sociale
core
Portrait de la situation en matière de recherche scientifique pour l’économie sociale du Canada [PDF]
, 2007 Ce rapport présente les premiers résultats d’une veille sur la recherche scientifique en économie sociale au Canada. Nous y avons répertorié divers organismes de recherche qui traitent de l’économie sociale et coopérative. Les critères de sélection étant
Goulet-Cloutier, Catherine +2 more
core
FEBS Open Bio, EarlyView.In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin +12 more
wiley +1 more source