Results 81 to 90 of about 1,574,400 (378)
Non-reciprocal few-photon devices based on chiral waveguide-emitter couplings
, 2016 We demonstrate the possibility of designing efficient, non reciprocal few-photon devices by exploiting the chiral coupling between two waveguide modes and a single quantum emitter. We show how this system can induce non-reciprocal photon transport at the
Garcia-Vidal, F. J. +3 more
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Problemos, 2020 In the paper I analyse Daniele Archibugi’s conception of the new cosmopolitanism, aimed at formulation of a theory of cosmopolitan democracy capable of facing contemporary global problems that go beyond the competences of nation-states.
Dorota Drałus
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Reciprocity: a fragile equilibrium [PDF]
Netherlands Journal of Legal Philosophy, 2014 Reciprocity: a fragile equilibrium Reciprocity may serve to explain or to justify law. In its latter capacity, which is the topic of this article, reciprocity is commonly turned into a highly idealized notion, as either a balance between two free and equal parties or as the possibility of communication tout court.
openaire +2 more sources
Irreversibility, heat and information flows induced by non-reciprocal interactions
New Journal of Physics, 2020 We study the thermodynamic properties induced by non-reciprocal interactions between stochastic degrees of freedom in time- and space-continuous systems. We show that, under fairly general conditions, non-reciprocal coupling alone implies a steady energy
S. Loos, S. Klapp
semanticscholar +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Saturated Gain-Induced Non-Reciprocal Transmission and Broadband On-Chip Optical Isolator
PhotonicsTo overcome the limitation of dynamic reciprocity, a new method for designing broadband on-chip optical isolators is proposed and demonstrated based on saturated gain, which is able to support simplex and duplex operation modes. By connecting a saturated
Mingyuan Xue +3 more
doaj +1 more source