Results 71 to 80 of about 482,932 (313)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Load distribution in flat reciprocal structures [PDF]

, 2023
The elements in conventional structures are perfectly ranked, so that load transmission is logical and follows the usual structural orders. Nevertheless, in reciprocal structures each element has to support all of the others in a less intuitive pattern ...
Laura Gonzalo Calderón, José Ramón Aira Zunzunegui, Gonzalo Calderón, Laura, Aira Zunzunegui, José Ramón   +3 more
core   +2 more sources

Reciprocal Cosmopolitanism

Problemos, 2020
In the paper I analyse Daniele Archibugi’s conception of the new cosmopolitanism, aimed at formulation of a theory of cosmopolitan democracy capable of facing contemporary global problems that go beyond the competences of nation-states.
Dorota Drałus
doaj   +1 more source

Reciprocity via Reciprocants

The American Mathematical Monthly
10 pages.
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Cytological, genetic and agronomic characterization of a barley reciprocal translocation [PDF]

, 2012
Cereals are the basis of global agriculture providing more than half of the human food consumption. In Spain, barley is the main crop in terms of growing area, mostly in the poorest agricultural areas.
Farré Martinez, Alba, Farré Martinez, A.   +1 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Chromosomal control of pig populations in France: 2002-2006 survey [PDF]

, 2007
The chromosomal control of pig populations has been widely developed in France over the last ten years. By December 31st, 2006, 13 765 individuals had been karyotyped in our laboratory, 62% of these since 2002.
BERLAND, H.M., Alain Pinton, Mary, Nicolas, Darré, Roland, Nicolas Mary, Alain Ducos, Roland Darré, Amélie Garnier-Bonnet, Hélène-Marie Berland, BILLOUX, S., Garnier-Bonnet, Amélie, BONNET, N., Ducos, Alain, Berland, Hélène-Marie, Bonnet, Nathalie, Anne Calgaro, Pinton, Alain, Billoux, Sébastien, Calgaro, Anne, Nathalie Bonnet, Sébastien Billoux, GARNIER-BONNET, A.   +21 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Saturated Gain-Induced Non-Reciprocal Transmission and Broadband On-Chip Optical Isolator

Photonics
To overcome the limitation of dynamic reciprocity, a new method for designing broadband on-chip optical isolators is proposed and demonstrated based on saturated gain, which is able to support simplex and duplex operation modes. By connecting a saturated
Mingyuan Xue, Haojiang Tong, Hao Dong, Meijia Wang   +3 more
doaj   +1 more source