Results 121 to 130 of about 452,570 (334)

Colorectal Cancer Cell's Weapon: RNF32 Engages SPP1+ Macrophages to Foster Liver Metastasis, Targeted by Indole‐3‐Acetic Acid

Advanced Science, EarlyView.
Cytoplasmic RNF32 fuels CRC liver metastasis by degrading GSK3β, which stabilizes β‐catenin and activates Wnt/EMT. Moreover, RNF32 rewires the metastatic niche: it depletes CD8+/CD4+ T and NK cells while recruiting SPP1+ macrophages (which boost tumor stemness via CD44), fibroblasts, and immunosuppressive monocytes to aid colonization.
Hongyu Wang, Shipeng Dai, Yuchen Xie, Pengyu Chen, Yue Chai, Chongyu Wang, Xueying Huang, Xiao Dong, Junfeng Shi, Yongxiang Xia, Xiaofeng Qian, Weiwei Tang, Yichan Zhou   +12 more
wiley   +1 more source

Case report: A reciprocal translocation-free and pathogenic DUOX2 mutation-free embryo selected by complicated preimplantation genetic testing resulted in a healthy live birth. [PDF]

Front Genet, 2023
Shi B, Ye Y.
europepmc   +1 more source

Traceless Regulation of Genetic Circuitry

Advanced Science, EarlyView.
Energy‐based, as opposed to molecular, control offers unprecedented improvements in key circuit parameters. This review summarizes the fundamentals of such traceless switches, categorizes them by trigger modalities, and compares and contrasts distinct advantages as well as shortcomings of each kind.
Gokberk Unal, Martin Fussenegger
wiley   +1 more source

Median cleft of upper lip and pedunculated skin masses associated with de novo reciprocal translocation 46,X,t(X;16)(q28;q11.2). [PDF]

, 1997
Mitsuo Masuno, K Imaizumi, Yoshihisa Fukushima, Yuh Tanaka, Taisuke Ishii, Mariko Nakamura, Y. Kuroki   +6 more
openalex   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Case Report: Balanced Reciprocal Translocation t (17; 22) (p11.2; q11.2) and 10q23.31 Microduplication in an Infertile Male Patient Suffering From Teratozoospermia. [PDF]

Front Genet, 2022
Huang S, Wu H, Qi Y, Wei L, Lv X, He Y.
europepmc   +1 more source

PGD in a 4;13 reciprocal translocation carrier addressed commonly multiplex QF-PCR

, 2012
Judith Mincman, María Eugenia Ducatelli, Alicia Gallo, Nicolás Neuspiller, Roberto Coco   +4 more
openalex   +1 more source

ROS‐Responsive Wedelolactone Hydrogel Promotes Intervertebral Disc Repair by Disrupting the NF‐κB–LCN2 Inflammatory Feedback Loop

Advanced Science, EarlyView.
A mechanically robust, ROS‐responsive hydrogel is engineered to treat intervertebral disc degeneration by targeting the NF‐κB–LCN2 inflammatory feedback loop. By delivering wedelolactone specifically within oxidative niches, this system disrupts macrophage–disc cell crosstalk.
Zimei Wu, Yan Xu, Lang Qin, Zemin Ling, Yingjie Mai, Xiong Tian Guo, Jiajia Chen, Leping Yan, Lin Wang, Liming Bian, Fuxin Wei   +10 more
wiley   +1 more source

Analysis of segregation patterns of quadrivalent structures and the effect on genome stability during meiosis in reciprocal translocation carriers

Human Reproduction, 2018
Shuo Zhang, Caixia Lei, Junping Wu, Haiyan Sun, Jing Zhou, Sai-juan Zhu, Jialong Wu, Jing Fu, Yijuan Sun, D. Lu, Xiaoxi Sun, Yue-ping Zhang   +11 more
semanticscholar   +1 more source

Conventional ICSI improves the euploid embryo rate in male reciprocal translocation carriers. [PDF]

J Assist Reprod Genet, 2021
Lei C, Zhang S, Zhu S, Wu J, Xiao M, Zhou J, Fu J, Sun Y, Xu C, Sun X.   +9 more
europepmc   +1 more source