Results 191 to 200 of about 39,375 (245)

Compartmentalisation in cAMP signalling: A phase separation perspective

open access: yesBritish Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

The tandem–random transition of cellular patterning: proposed roles of N‐cadherin‐based orientational cell adhesions in the development, maintenance, and degeneration of the nucleus pulposus

open access: yesBiological Reviews, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) can contribute to lower back and neck pain. In IDD, the most affected component of the intervertebral disc is the nucleus pulposus (NP). Derived from the notochord, where cells are organized into a tandem configuration, young NP cells cluster in three‐dimensional (3D) networks embedded in a gelatinous ...
Xiangyun Wei, Nam Vo, Gwendolyn A. Sowa
wiley   +1 more source

From beginning to end: the synecology of tree‐killing bark beetles, fungi, and trees

open access: yesBiological Reviews, EarlyView.
ABSTRACT Over a century of research has revealed an amazing complexity of behaviours and physiological adaptations that allow tiny bark beetles to overcome large trees, sometimes resulting in outbreaks that kill millions of trees. Turning a tree into a home and successfully raising offspring involves constant interactions among the beetles, the tree ...
Diana L. Six   +3 more
wiley   +1 more source

An integrated social–ecological–evolutionary–phenotypic (SEEP) approach to understanding animal responses to urbanization

open access: yesBiological Reviews, EarlyView.
ABSTRACT Humans play key roles in shaping the structure and processes of ecosystems globally, especially in cities. This recognition has prompted a recent focus on understanding urban systems via interactions between human social systems and ecological and evolutionary processes.
Kevin E. McCluney   +9 more
wiley   +1 more source

Mapping allele with resolved carrier status of Robertsonian and reciprocal translocation in human preimplantation embryos. [PDF]

open access: yesProc Natl Acad Sci U S A, 2017
Xu J   +24 more
europepmc   +1 more source

Comparative Analysis of a Dual DNA–RNA Panel and a DNA‐Only Panel for Sarcoma: Real‐World Data From a Nationwide Genomic Database

open access: yesCancer Science, EarlyView.
Dual DNA–RNA panel with matched tumor–normal testing may improve diagnostic accuracy and inform treatment decisions in the routine clinical management of sarcoma. ABSTRACT Next‐generation sequencing‐based comprehensive cancer genomic profiling is promising in cancer management; however, most studies rely on tumor‐only DNA panels from single ...
Eiji Nakata   +10 more
wiley   +1 more source

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