Results 211 to 220 of about 85,080 (296)

Synergistic RU486 and olaparib therapy enhances apoptosis in endometriosis by simultaneously targeting hormonal signalling and DNA repair

British Journal of Pharmacology, EarlyView.
Background and Purpose Endometriosis is a chronic, hormone‐dependent disorder characterized by ectopic implantation of endometrial tissue, often accompanied by pain and infertility. Although the progesterone receptor modulator RU486 is effective for pain relief, its impact on lesion regression is limited, possibly due to apoptosis resistance and ...
Yujie Peng, Meng Zhang, Libo Zhu, Wenqiang Qian, Jingjing Yan, Huidi Jiang, Yu Xin, Ying Zhang, Dongli Sun, Weidong Fei, Mengdan Zhao   +10 more
wiley   +1 more source

The decision on the embryo to transfer after Preimplantation Genetic Diagnosis for X-autosome reciprocal translocation in male carrier. [PDF]

Mol Cytogenet, 2018
Chamayou S, Sicali M, Lombardo D, Alecci C, Guglielmino A.   +4 more
europepmc   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Oncolytic Vaccinia Virus‐HSP70‐shRNA Amplifies Viral Replication, ROS/Autophagy, and Immunity to Fight Colorectal Cancer

Cancer Science, EarlyView.
OncoVV‑shHSP70, a vaccinia virus silencing HSP70, demonstrated potent antitumor efficacy in colorectal cancer cell lines, as well as in syngeneic, xenograft, and humanized mouse models. In cell lines, oncoVV‑shHSP70 promoted viral oncolysis and cytokine production through a self‑reinforcing cycle of ROS‑autophagy. In both CT26 and SW620‑humanized mouse
Rentao Yuan, Ruikang Liu, Fangying Shao, Zheqi Cai, Yingfei Fang, Kan Chen, Yanrong Zhou, Ting Ye, Gongchu Li   +8 more
wiley   +1 more source

A new reciprocal translocation involving chromosomes 1/14 in a boar

Genetics Selection Evolution, 1987
Franchi Fabrizia, Tarocco C, Croci G
doaj   +1 more source

Advancing conservation breeding programs for marine invertebrates

Conservation Biology, EarlyView.
Abstract In the face of ecosystem change and biodiversity loss caused by climate change and other stressors, conservation breeding, or captive breeding, with the aim of reintroduction for wild population recovery, is an emerging tool for preventing species’ extinction and rehabilitating ecosystems.
Elora H. López‐Nandam, Bart Shepherd, Kylie Lev, Rebecca Albright   +3 more
wiley   +1 more source

Multiple occurrence of psychomotor retardation and recurrent miscarriages in a family with a submicroscopic reciprocal translocation t(7;17)(p22;p13.2). [PDF]

BMC Med Genomics, 2018
Pasińska M, Łazarczyk E, Jułga K, Bartnik-Głaska M, Nowakowska B, Haus O.   +5 more
europepmc   +1 more source

Coinvasional disruptions to island pollinator networks

Conservation Biology, EarlyView.
Abstract Biological invasions can adversely affect pollinator diversity by threatening the maintenance of animal‐pollinated plant communities. Although most studies have examined single invasive species, accelerating species introductions driven by global trade highlight the need to understand how multiple co‐occurring invaders jointly influence ...
Marta Quitián, Isaac Planas‐Sitjà, Maki Morooka, Anna Traveset, Simon M. Tierney, Adam L. Cronin   +5 more
wiley   +1 more source

Predicting people's priorities for reconciling food security and biodiversity conservation in Kasungu, Malawi

Conservation Science and Practice, EarlyView.
Predicted probabilities of perceived food security outcomes under different conservation and livelihood scenarios, disaggregated by household location. Abstract Balancing agricultural productivity with biodiversity conservation is a critical challenge in rural Africa, where food insecurity and poverty intersect with growing ecological pressures ...
Lessah Mandoloma, Henry Travers, Michael Clark, Lauren Coad, Karl Hughes, E. J. Milner‐Gulland   +5 more
wiley   +1 more source