Results 191 to 200 of about 85,080 (296)
The Origin and Evolution of Chromosomal Reciprocal Translocation in Quasipaa boulengeri (Anura, Dicroglossidae). [PDF]
Front Genet, 2019 Xia Y, Yuan X, Luo W, Yuan S, Zeng X.
europepmc +1 more source
Uric Acid in Metabolic Dysfunction‐Associated Steatotic Liver Disease
Portal Hypertension &Cirrhosis, EarlyView.MASLD is the most prevalent chronic liver disease worldwide, yet effective pharmacological treatments remain limited. Hyperuricemia is now recognized as a key driver of hepatic steatosis, inflammation, and fibrosis, with elevated serum uric acid levels independently predicting hepatocellular carcinoma and liver‐related mortality.
Rong Wang +5 more
wiley +1 more source
Past, present and future of local crop evolution
PLANTS, PEOPLE, PLANET, EarlyView.Promoting agrobiodiversity is a promising strategy for mitigating the negative effects of climate change on global food security. We highlight the central role evolutionary processes play in harnessing the potential of local crops by integrating genomics, archaeology, ethnobotany and traditional ecological knowledge (TEK).
Nataly Allasi Canales +6 more
wiley +1 more source
Non-Random Distribution of Reciprocal Translocation Breakpoints in the Pig Genome. [PDF]
Genes (Basel), 2019 Donaldson B +4 more
europepmc +1 more source
Allosteric Regulation of RNA Affinity by Motif V‐VI Coupling in West Nile Virus NS3 Helicase
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT The rise of flaviviral diseases, including West Nile virus (WNV), presents a growing threat to global public health and underscores the urgent need for new therapeutic strategies. The non‐structural protein 3 helicase (NS3h) of the Orthoflavivirus genus, including WNV, is essential for viral replication and a promising antiviral target ...
Priti Roy, Martin McCullagh
wiley +1 more source
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT The role of the cell envelope‐associated Rv0132c/FGD2 from Mycobacterium tuberculosis has long been a subject of debate. Importantly, FGD2 is found only in pathogenic mycobacteria, making it a potential drug target. While some suggest it functions as a glucose‐6‐phosphate dehydrogenase, others propose it acts instead as an F420‐dependent ...
Adewale V. Aderemi +12 more
wiley +1 more source
Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy
Phytotherapy Research, EarlyView.Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee +9 more
wiley +1 more source
Phytotherapy Research, EarlyView.ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative condition characterized by a preclinical stage that typically lasts for decades. Early on during this time, microglia react to pathological changes and become protective and even transiently delay neurodegeneration.
Sara Merlo +3 more
wiley +1 more source
Small, EarlyView.A scalable fabrication method based on chemically tuned controlled dielectric breakdown (CT‐CDB) enables heterogeneous multilayer nanopores integrating SiNx with 2D materials such as hBN, MoS2, and graphene. The resulting nanopores exhibit distinct electrokinetic behaviors and low noise, allowing structure‐dependent single‐protein sensing.
Chaoming Gu +9 more
wiley +1 more source
A reciprocal translocation radically reshapes sex-linked inheritance in the common frog. [PDF]
Mol Ecol, 2019 Toups MA +3 more
europepmc +1 more source