Results 81 to 90 of about 39,375 (245)

Rapid mapping of chromosomal breakpoints: from blood to BAC in 20 days.

Folia Histochemica et Cytobiologica, 2010
Structural chromosome aberrations and associated segmental or chromosomal aneusomies are major causes of reproductive failure in humans. Despite the fact that carriers of reciprocal balanced translocation often have no other clinical symptoms or disease,
Mei Wang, Adolf Baumgartner, Jingly F Weier, Johnson Kwan, Chun-Mei Lu, Tomas Escudero, Santiago MunnĂŠ, Heinz-Ulrich G Weier   +7 more
doaj   +1 more source

Partial Reprogramming in Senescent Schwann Cells Enhances Peripheral Nerve Regeneration via Restoration of Stress Granule Homeostasis

Advanced Science, EarlyView.
In this study, it is discovered that pathological accumulation of Runx2+ Schwann cell clusters​ during axonal regeneration is a key factor impairing nerve repair in aging. This pathology is associated with ​dysregulation of stress granule homeostasis.
Peilin Wang, Renyuan Wang, Yilin Huo, Ying Peng, Chuanliang Fu, Yi Hu, Zun Ren, Yersen Mulat, Hao Zhang, Dongsheng Jiang, Haodong Lin   +10 more
wiley   +1 more source

Acampomelic campomelic dysplasia with de novo 5q;17q reciprocal translocation and severe phenotype. [PDF]

, 1998
Ravi Savarirayan, Agnes Bankier
openalex   +1 more source

Mechanical Force Storage and Reprogramming Hydrogel for Scarless Repair of Sports Joint Wounds

Advanced Science, EarlyView.
Inspired by the energy conversion of tendons, the “energy transit station” hydrogel is designed. The hydrogel not only shields stress concentration in sports injuries, but also reprograms energy forms to provide reasonable biomimetic contraction for wounds.
Jiakang Zhang, Yuhui Zhang, Yuanru Lang, Tao Fu, Qian Liu, Long Chen, Peng Zhang, Yan Xiao, Yuntong Zhang, Shuo Fang, Meidong Lang   +10 more
wiley   +1 more source

TICdb: a collection of gene-mapped translocation breakpoints in cancer

BMC Genomics, 2007
Background Despite the importance of chromosomal translocations in the initiation and/or progression of cancer, a comprehensive catalog of translocation breakpoints in which these are precisely located on the reference sequence of the human genome is not
de Mendíbil Iñigo, Novo Francisco J, Vizmanos José L   +2 more
doaj   +1 more source

Punicalagin Enhances Autophagy Through Sirtuin 1/FoxO3a Axis to Inhibit Intracellular Mycobacterium Abscessus Infection

Advanced Science, EarlyView.
Punicalagin, a pomegranate molecule, helps the body fight Mycobacterium abscessus. It preferentially boosts interstitial macrophages in the lung, stabilizing mitochondria and switching on the autophagy via SIRT1/FoxO3a, which lowers bacterial load without directly killing bacteria.
Kefan Bi, Bihan Xu, Dan Cao, Kaijin Xu, Ying Zhang   +4 more
wiley   +1 more source

AID Produces DNA Double-Strand Breaks in Non-Ig Genes and Mature B Cell Lymphomas with Reciprocal Chromosome Translocations [PDF]

, 2009
Davide F. Robbiani, Samuel F. Bunting, Niklas Feldhahn, Anne Bothmer, Jordi Camps, Stephanie Deroubaix, Kevin M. McBride, Isaac A. Klein, Gary Stone, Thomas Eisenreich, Thomas Ried, André Nussenzweig, Michel C. Nussenzweig   +12 more
openalex   +1 more source

Decreased RYR2 Cluster Size and Abnormal SR Ca2+ Release Contribute to Arrhythmogenesis in TMEM43‐Related ARVC

Advanced Science, EarlyView.
The TMEM43 ‐ P386S mutation causes arrhythmogenic right ventricular cardiomyopathy (ARVC) by mislocalizing itself from nuclear envelope (NE) to cytoplasm, disrupting lamin B2 (a novel TMEM43 interactor) localization, NE integrity and chromatin accessibility, causing hyper ‐ phosphorylation and reduced expression/clustering of ryanodine receptor type 2 (
Jiaxi Shen, Xiaochen Wang, Hangping Fan, Yaxun Sun, Tingyu Gong, Hangyuan Qiu, Jue Wang, Ziwei Pan, Yanna Dang, Hongkun Wang, Danni Zhou, Tianyi Zhu, Hao Wang, Xianzhen Chen, Lizhen Xu, Jun Su, Fan Yang, Yiquan Tang, Xuguang Li, Bing Yang, Lenan Zhuang, Wei Wang, Chenyang Jiang, Ping Liang   +23 more
wiley   +1 more source

Partial trisomy 13q resulting from a paternal reciprocal Yq;13q translocation. [PDF]

, 1991
J. Nikoliš, K Ivanovic, V. Diklić
openalex   +1 more source

Mild Photothermal Bimetallic Mesoporous Nanozyme Triggers Immunogenic Cell Death and Immune Contexture Remodeling for Precision Hepatocellular Carcinoma Treatment

Advanced Science, EarlyView.
In this study, a Pt/Co BNzyme with peroxidase/GPx‐like activity is developed, increasing oxidative stress by generating ROS and depleting GSH to induce ICD. The mild PTT effect enhanced its enzymatic activity. The Pt/Co BNzyme remodeled the TME, promoting DC maturation.
Yanbing Huang, Lei Ding, Yanbing Cao, Qiang Feng, Yanjuan Li, Jianmin Wang, Zhixiong Cai, Fuli Xin, Peiyuan Wang, Jingfeng Liu   +9 more
wiley   +1 more source