Results 41 to 50 of about 231,004 (274)

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

THE USE OF PRETREATMENT OF PLANT SEEDS TO OVERCOME THE PHYTOTOXICITY OF MINE WASTE DUMPS DURING THEIR BIOLOGICAL RECLAMATION [PDF]

open access: yes, 2018
Donbass is one of the oldest and largest coal mining regions in Ukraine and the world. For today there are more than 1300 dumps in Donetsk and Luhansk regions, the main part of which are located within the cities.
Borodenko, Maria, Ruban, Elina
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Identification of Quality-Related Genomic Regions and Candidate Genes in Silage Maize by Combining GWAS and Meta-Analysis

open access: yesPlants
Enhancing quality traits is a primary objective in silage maize breeding programs. The use of genome-wide association studies (GWAS) for quality traits, in combination with the integration of genetic resources, presents an opportunity to identify crucial
Yantian Lu   +7 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Effect of partial root-zone drying on grafted tomato in commercial greenhouse

open access: yesHorticultural Science, 2020
For two years, the tomatoes (cv. 'Belle' and 'Clarabella'), ungrafted, self-grafted and grafted onto the 'He-man' rootstock, were grown under two irrigation regimes, i.e., partial-root zone drying (PRD) and fully irrigated (FI), to investigate whether ...
Branimir Urlić   +6 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

Penguasaan Tanah Reklamasi tanpa Alas Hak atas Tanah: Studi Kasus di Desa Taddan, Kecamatan Camplong, Kabupaten Sampang

open access: yesLentera Hukum, 2018
This study discuss legal issues concerning control of reclamation without possessing land rights as the result of the unregistered reclamation by communities in the Village of Tanddan, Sub-district Campling in the Sampang Regency.
Amri Ubaidillah
doaj   +1 more source

RECLAMATION THE BEACH OF SANUR: ECONOMIC AND SOCIA-CULTURAL PERSPECTIVE OF THE BALINESE COMMUNITY [PDF]

open access: yes, 2010
This article is based on a research impact of beach reclamation in relation to the economic and socio-cultural social of the people in the Sanur tourism area.
I Made, Darma Oka
core  

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

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