Results 101 to 110 of about 3,252,241 (308)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
SteuerLLM: local specialized large language model for German tax law analysis
Scientific ReportsLarge language models (LLMs) demonstrate strong general reasoning and language understanding, yet their performance degrades in domains governed by strict formal rules, precise terminology, and legally binding structure.
Sebastian Wind +10 more
doaj +1 more source
Comparison of Feature Learning Methods for Human Activity Recognition Using Wearable Sensors
Sensors, 2018 Getting a good feature representation of data is paramount for Human Activity Recognition (HAR) using wearable sensors. An increasing number of feature learning approaches—in particular deep-learning based—have been proposed to extract an effective ...
Frédéric Li +4 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Academic Career Paths: A Design Workshop
This workshop supports in developing differentiated career paths, by involving academics in co-design sessions to ensure that new Academic Paths reflect their needs and aspirations.
Recognition & Rewards
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Locality-Regularized Linear Regression for Face Recognition
, 2012 Linear Regression Classification (LRC) based face recognition achieves high accuracy while being highly efficient. As with most other linear-subspace-based methods, the faces of a subject are assumed to reside on a linear manifold; however, where ...
Brown, Douglas +2 more
core
Academic Career Paths: A Journey from Planning to Evaluation
This tool contains guidelines for introducing differentiated career paths at a School of a university, from the very first preparatory activities to the post-evaluation actions.
Recognition & Rewards
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Unlock Your Team Potential: A Hand-on Workshop
The Unlock your team potential workshop gives team leads and those who work in a team the opportunity to experiment with the variety of talents and interests within a team.
Recognition & Rewards
core +1 more source