Results 121 to 130 of about 6,852,344 (341)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Feedback Recorrection Semantic-Based Image Inpainting Under Semi-Supervised Learning

Sensors
Image semantics, by revealing rich structural information, provides crucial guidance for image inpainting. However, current semantic-guided inpainting frameworks generally operate unidirectionally, relying on pre-trained segmentation networks without a ...
Xueyi Ye, Ruijie Tan, Mingcong Sui, Huahua Chen, Na Ying   +4 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Graph neural network and machine learning analysis of functional neuroimaging for understanding schizophrenia

BMC Neuroscience
Background Graph representational learning can detect topological patterns by leveraging both the network structure as well as nodal features. The basis of our exploration involves the application of graph neural network architectures and machine ...
Gayathri Sunil, Smruthi Gowtham, Anurita Bose, Samhitha Harish, Gowri Srinivasa   +4 more
doaj   +1 more source

Conceptual Challenges to the Recognition and Enforcement of the Right to Clean, Safe and Healthy Environment

, 2022
Brown Umukoro, Oghenerukevwe Ituru
openalex   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Static and dynamic 3D facial expression recognition: A comprehensive survey

, 2012
Georgia Sandbach, Stefanos Zafeiriou, Maja Pantić, Lijun Yin   +3 more
openalex   +2 more sources

TLR4, NOD1 and NOD2 mediate immune recognition of putative newly identified periodontal pathogens

, 2020
Kinney,, Giannobile,, Schaff, Gerow,, Marchesan,, Jiao,, Gerow, Paster,, Sheridan,, Paster, Inohara, Hao,   +11 more
openalex   +1 more source