Results 91 to 100 of about 12,083 (257)

A Phase‐Resolved Geometric Deep Learning Framework Maps Structural Determinants of Disease‐Associated Protein Aggregation and Guides Suppressor Design

Advanced Science, EarlyView.
SKALE 2.0 maps disease‐associated protein aggregation as a phase‐resolved structural process, linking mutation‐induced geometric perturbations to nucleation, elongation, and suppressor design. Across neurodegenerative proteins, the framework reveals cryptic aggregation vulnerabilities, separates phase‐concordant and phase‐switching mutations, and ...
Jia Shen Sio, Wei Xuan Wilson Loo, Yan Shan Loo, Wen Xin Tan, Hui Xuan Lim, Huitao Liu, Chen Seng Ng   +6 more
wiley   +1 more source

Rod Origami (RodOri) Spring Metamaterials for Tunable Vibration Control via Tailored Structural Instabilities

Advanced Science, EarlyView.
Rod Origami (RodOri) springs harness snap‐through instabilities of pre‐stressed curved rods with geometrically programmable buckling behavior. Integrating RodOri springs with distinct geometries yields multistable metamaterials that undergo stepwise reconfiguration via sequential snapping, achieving wide‐range tunability of stiffness and resonance ...
Jeseung Lee, Sophie Leanza, Ruike Renee Zhao   +2 more
wiley   +1 more source

Remembering for the Future [PDF]

Estudios Irlandeses
This article problematises the State’s role in decreeing, overseeing and promulgating “official history” and explores the work of museum curators, historical filmmakers and public historians to expose the complexity that vitiates official narratives ...
Maurice Fitzpatrick
doaj  

A Versatile‐Designable Framework for Active and Programmable Shape‐Morphing Soft Matter Systems: From Inverse Design to Closed‐Loop Control

Advanced Science, EarlyView.
A versatile framework integrates addressable electrothermal actuation and strain‐constraint mechanisms to construct programmable shape‐morphing soft matter systems. By combining an analytical inverse design strategy for high‐fidelity 3D surface reconstruction with deep learning‐based closed‐loop control, this approach enables zero‐energy shape locking,
Kai Liu, Peiling Xie, Ruitong Song, Banghan Liu, Rui Guo, Jiu‐an Lv   +5 more
wiley   +1 more source

Multi‐Component Functionalized Bifidobacterium Longum Hydrogel for Multi‐Target Integrated Therapy of Colitis‐Associated Anxiety and Depression

Advanced Science, EarlyView.
A pH/MMP dual‐responsive Bifidobacterium longum (BL) hydrogel (INPs@BL@Gel) functionalized with baicalin, tyrosine, and inulin is constructed. It enables gastric protection, inflammation‐targeted release, and prolonged intestinal colonization. By remodeling gut microbiota, elevating beneficial neuroactive metabolites (homovanillic acid, short‐chain ...
Shuo Zhang, Yujie Zhang, Jiansheng He, Shunlian Li, Qingyan Ma, Qiao Li, Yudan Zhang, Yiyang Wang, Shaobo Ma, Songyan Jin, Chune Li, Xueyong Xie, Hang Zhang, Junze Deng, Xueqin Song, Daocheng Wu, Xiancang Ma, Feng Zhu   +17 more
wiley   +1 more source

Light‐Activated Ruthenium Nanoclusters Reprogram the Metabolic‐Quorum Sensing Axis for Precision Periodontitis Therapy

Advanced Science, EarlyView.
Under 660 nm visible light, Ru NCs efficiently photocatalyze nitrate‐to‐ammonium conversion and modulate oral nitrogen metabolism. They precisely perturb Veillonella parvula, block its key support to Porphyromonas gingivalis, and exert an “inhibiting without killing” antivirulence effect.
Jing Zhou, Xiaolin Sun, Chengyu Liu, Yujia Shi, Meiqi Li, Meng Bo, Jingjie Zhai, Chunyan Li, Zhennan Wu, Xue Bai, Lin Wang   +10 more
wiley   +1 more source

Unveiling Activation Process of C═N Cathode for High‐Performing Zinc‐Organic Batteries

Advanced Science, EarlyView.
A high‐performance organic cathode of DPPT has been designed for aqueous zinc‐ion batteries (ZIBs), showing ultralong cycle life of 45 000 cycles. Besides, flexible DPPT ZIBs with stable capacity are applied in wearable NH3 sensors. Notably, the activation mechanism of the transformation of DPPT‐eight proton into DPPT is proposed and proved which ...
Xiaodong Geng, Zhangyu Wang, Weiyao Bi, Qian Zhao, Hongting Ma, Kai Yang, Ying Liu, Zhiqian Li, Qinghua Deng, Dan Zhao, Yuqian Jiang, Nan Zhu   +11 more
wiley   +1 more source

Bioinspired Multifunctional Flexible C‐SiC Fibrous Aerogel for Superior Electromagnetic Interference Shielding Under Extreme Environments

Advanced Science, EarlyView.
This schematic presents a biomimetic C‐SiC fibrous aerogel inspired by the special structure of momordica charantia. It exhibits outstanding thermal insulation and ultrahigh specific electromagnetic shielding performance, together with excellent high‐temperature stability and mechanical flexibility, showing great promise for aerospace applications ...
Tianyue Yang, Yan Shen, Zhongqian Zhao, Xue Zhou, Qianji Chen, Xujing Wang, Chuchu Zheng, Zhaoxiang Lu, Yangzhong Zhao, Yanzi Gou   +9 more
wiley   +1 more source

Hybrid Paul-optical trap with large optical access for levitated optomechanics

Physical Review Research
We present a hybrid trapping platform that allows us to levitate a charged nanoparticle in high vacuum using either optical fields, radio-frequency fields, or a combination thereof.
Eric Bonvin, Louisiane Devaud, Massimiliano Rossi, Andrei Militaru, Lorenzo Dania, Dmitry S. Bykov, Markus Teller, Tracy E. Northup, Lukas Novotny, Martin Frimmer   +9 more
doaj   +1 more source

Calcineurin‐Dependent Stress Adaptation Enables Caspofungin Heteroresistance Leading to Stable Resistance in Candida Glabrata

Advanced Science, EarlyView.
Caspofungin heteroresistance is prevalent in clinical Candida glabrata isolates and depends on calcineurin‐mediated stress adaptation. This transient phenotype serves as a reservoir for resistance evolution, enabling the emergence of stable resistant descendants under prolonged drug pressure.
Yanyu Su, Yi Li, Meng Xiao, Dan Guo, David S. Perlin, Erika Shor, Yingchun Xu, Yingxing Li   +7 more
wiley   +1 more source