Results 51 to 60 of about 66,901 (296)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

open access: yesMolecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen   +19 more
wiley   +1 more source

Impact of diabetes on the accuracy and speed of accessing information from episodic and working memory

open access: yesCogent Psychology, 2021
The aim of the study was to evaluate the effects of diabetes on episodic memory and working memory after controlling for other comorbidities and several demographic and biological variables.
Selene Cansino   +5 more
doaj   +1 more source

Aristotle’s On Memory and Recollection: Concepts, Sources, and Innovations of Aristotle’s Account of Mnemonic Capacities and Activities [PDF]

open access: yes, 2009
My thesis inquires into some of the most relevant problems of Aristotle’s treatise On memory and recollection. The first chapter consists in an analysis of the keywords of the work.
MEDDA, ROBERTO
core  

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

Do young children, like young adults, remember animates better than inanimates?

open access: yesFrontiers in Psychology, 2023
It has repeatedly been shown in adults that animates are remembered better than inanimates. According to the adaptive view of human memory this is due to the fact that animates are generally more important for survival than inanimates.
Aurélia Bugaiska   +2 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Multiple Exposures Enhance Both Item Memory and Contextual Memory Over Time

open access: yesFrontiers in Psychology, 2020
Repetition learning is an efficient way to enhance memory performance in our daily lives and educational practice. However, it is unclear to what extent repetition or multiple exposures modulate different types of memory over time.
Haoyu Chen   +3 more
doaj   +1 more source

Examining the relationship between processing fluency and memory for source information

open access: yesRoyal Society Open Science, 2021
Familiarity-based processes such as processing fluency can influence memory judgements in tests of item recognition. Many conventional accounts of source memory assume minimal influence of familiarity on source memory, but recent work has suggested that ...
Tina S.-T. Huang, David R. Shanks
doaj   +1 more source

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