Durability of Response to B‐Cell Maturation Antigen‐Directed mRNA Cell Therapy in Myasthenia Gravis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective We report the 12‐month follow‐up outcomes from a Phase 2 clinical trial (NCT04146051) evaluating Descartes‐08, a BCMA‐directed RNA chimeric antigen receptor T‐cell (rCAR‐T) therapy for refractory generalized myasthenia gravis (MG).
Nizar Chahin +10 more
wiley +1 more source
SNUPN‐Related Muscular Dystrophy: Novel Phenotypic, Pathological and Functional Protein Insights
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective SNUPN‐related muscular dystrophy or LGMDR29 is a new entity that covers from a congenital or childhood onset pure muscular dystrophy to more complex phenotypes combining neurodevelopmental features, cataracts, or spinocerebellar ataxia. So far, 12 different variants have been described.
Nuria Muelas +18 more
wiley +1 more source
Safety and immunogenicity of two recombinant DNA COVID-19 vaccines containing the coding regions of the spike or spike and nucleocapsid proteins: an interim analysis of two open-label, non-randomised, phase 1 trials in healthy adults. [PDF]
Lancet Microbe, 2022 Ahn JY +17 more
europepmc +1 more source
An Enhancing Role for DNA Synthesis in Formation of Bacteriophage Lambda Recombinants [PDF]
, 1972 Franklin W. Stahl +3 more
openalex +1 more source
Cloning and Sequencing cDNA Encoding for Rhoptry-2 Toxoplasma Gondii Tachyzoite Local Isolate
Indonesian Journal of Biotechnology, 2015 Rhoptry protein belongs to an excretory and secretory antigens (ESAs) that play an important role during activepenetration of parasite into the cell target. This protein an able Toxoplasma gondii to actively penetrate targetedcell, meanwhile ESAs protein
Wayan T. Artama +4 more
doaj +2 more sources
US drug companies push for changes in recombinant DNA guidelines [PDF]
, 1979 David Dickson
openalex +1 more source
Bioorthogonal Engineering of Cellular Microenvironments Using Isonitrile Ligations
Advanced Functional Materials, EarlyView.Highly selective chemistries are required for fabrication and post‐cross–linking modification of cell‐encapsulating hydrogels used in tissue engineering applications. Isonitrile ligation reactions represent a promising class of bioorthogonal chemistries for engineering hydrogel‐based cellular microenvironments. Isonitrile‐based hydrogels are stable and
Ping Zhou +2 more
wiley +1 more source
The Insights of Radical Science in the CRISPR Gene-Editing Era: A History of Science for the People and the Cambridge Recombinant DNA Controversy. [PDF]
Sci Cult (Lond), 2021 Botelho A.
europepmc +1 more source
US expected to exempt most recombinant DNA experiments from federal regulation [PDF]
, 1979 David Dickson
openalex +1 more source