Tracing and Capturing the Epiblast Pluripotency of Sheep Preimplantation Embryos
This study performs a comprehensive single‐cell transcriptome analysis of sheep embryos from embryonic (E) day 1 to E14 to elucidate the mechanism of early lineage specification and the pluripotency changes (naïve, formative, and primed) of epiblast.
Jinying Zhang+28 more
wiley +1 more source
Sheep immune response against a novel recombinant enterotoxemia and infectious necrotic hepatitis vaccine in Türkiye. [PDF]
Ekinoğlu DN+5 more
europepmc +1 more source
Molecular evidence of an isolate of mungbean yellow mosaic India virus with a recombinant DNA B component occurring on mungbean from mid-hills of Meghalaya, India. [PDF]
Banerjee A, Umbrey Y, Yadav RM, Roy S.
europepmc +1 more source
The recombinant DNA revolution: implications for diagnosis and prevention of inherited disease
Hans‐Hilger Ropers, Berend Wieringa
openalex +1 more source
This study identifies MTCH2 as a crucial regulator of ferroptosis in colorectal cancer (CRC) progression. High expression of MTCH2 is correlated with poor prognosis in CRC patients. Furthermore, MTCH2 depletion induces ferroptosis to suppress CRC liver metastasis via the E2F4/TFRC axis and sensitizes tumors to sorafenib treatment, supporting MTCH2 as a
Pu Xing+18 more
wiley +1 more source
Phosphorylation of the protamine-like protein from baculovirus affects its DNA binding and virus propagation. [PDF]
Cheng Q+7 more
europepmc +1 more source
A Phase‐Separated SR Protein Reprograms Host Pre‐mRNA Splicing to Enhance Disease Susceptibility
This study identifies SR30, a splicing factor, as a negative regulator of tomato immunity. During Phytophthora infestans infection, the elevated SR30 forms nuclear condensates to suppress the alternative splicing (AS) of defense‐related genes in a phase separation manner.
Dong Yan+11 more
wiley +1 more source
Simple and robust in vivo engineering of plasmid DNA at any copy number in Escherichia coli. [PDF]
Sepulchro AGV+2 more
europepmc +1 more source
Historical perspectives pertaining to the NIH Recombinant DNA Advisory Committee. [PDF]
Wivel NA.
europepmc +1 more source
Inflammatory dysregulation drives intervertebral disc degeneration via stage‐dependent immune cellular dynamics. Single‐cell transcriptomics and genetic risk mapping revealed a shift from LCN2high myeloid‐derived suppressor cells maintaining disc repair in early stages to IL1B+ macrophage‐dominated pathology in advanced disease.
Changmeng Zhang+6 more
wiley +1 more source