Results 191 to 200 of about 611,895 (310)

From Jenner to genomics: the unfolding future of vaccinology. [PDF]

Front Immunol
Batool R.
europepmc   +1 more source

Prenatal Gene Transfer: Scientific, Medical, and Ethical Issues: A Report of the Recombinant DNA Advisory Committee

, 2000
National Institutes of Health [NIH] (United States). Recombinant DNA Advisory Committee
core  

RBM10 Deficiency Promotes Anti‐PD‐1 Resistance in LUAD via STING Alternative Splicing‐Driven CCL7 Signaling and Macrophage Polarization

Advanced Science, EarlyView.
RBM10 deficiency promotes anti‐PD‐1 resistance in lung adenocarcinoma by altering STING alternative splicing, which enhances CCL7 secretion and CCR2‐dependent M2 macrophage polarization. A positive feedback loop via mitochondrial transfer sustains this immunosuppression.
Weitong Gao, Ruqiong Wang, Bo An, Lishuang Qi, Zihan Jing, Xingmei Ren, Yang Zhou, Mingjun Xu, Jiaojiao Li, Jie Liu, Liying Wang, Gang Xu, Rou Li, Dexin Jia, Yan Yu   +14 more
wiley   +1 more source

Therapeutic hepatitis B vaccine employing DNA prime - MVA boost scheme requires additional priming with recombinant HBsAg to elicit an adequate antibody response. [PDF]

Front Immunol
Kerth HA, Kächele M, Müller N, Singh S, Tulessin M, Sacherl J, Ates Öz E, Su J, Bester R, Miko S, Steiger K, Mogler C, Busch DH, Wettengel JM, Protzer U, Kosinska AD.   +15 more
europepmc   +1 more source

Recombinant DNA Advisory Committee (RAC): 91st meeting of the NIH RAC

, 2003
National Institutes of Health [NIH] (United States). Recombinant DNA Advisory Committee [RAC]
core  

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

A rapid yeast-based reverse genetics system reveals SARS-CoV-2 Omicron BA.2.86 variant spreads faster than Omicron JN.1 variant in primary human nasal and bronchial epithelial airway cultures. [PDF]

mBio
Xu J, Chamblee M, Hsu CC, Jiang F, Chen P, Zhang Y, Liang X, Amer AO, Boyaka PN, Cormet-Boyaka E, Peeples ME, Li J.   +11 more
europepmc   +1 more source

Evaluation on the efficacy and immunogenicity of recombinant DNA plasmids expressing S gene from porcine epidemic diarrhea virus and VP7 gene from porcine rotavirus. [PDF]

Braz J Microbiol, 2019
Yin Y, Zhu L, Liu P, Zhao J, Fan Y, Sun X, Xu Z.   +6 more
europepmc   +1 more source

Recombinant DNA Advisory Committee (RAC): meeting agenda September 19-20, 2002

, 2003
National Institutes of Health [NIH] (United States). Recombinant DNA Advisory Committee [RAC]
core  

S100A14 in Tumor‐Derived EVs Targets PIAS3 to Reprogram Astrocytes and Induce Immunosuppressive Microenvironment Promoting Brain Metastasis and Germacrone Reversal Effect

Advanced Science, EarlyView.
This study identifies S100A14 in tumor‐derived exosomes as a key driver of brain metastasis. S100A14 targets PIAS3 in astrocytes, activating STAT3 signaling and promoting immunosuppressive MDSCs recruitment via chemokine secretion. Germacrone, a natural compound, binds S100A14 to disrupt this axis, effectively inhibiting brain metastasis with low ...
Qian Feng, Xia Yang, Lin An, Xue‐Yu Wang, Ming‐Rui Wang, Zhuo‐Hong Cai, Cai‐Jun Xie, Li‐Jun Qiao, You‐Bi Shen, Xi‐Min Liang, Rong Zhang, Cai‐Yan Wang, Zhong‐Qiu Liu, Rong‐Rong Zhang   +13 more
wiley   +1 more source