Results 241 to 250 of about 892,210 (336)

FBXO44 Regulates FOXP1 Degradation Through AURKA‐Dependent Phosphorylation to Promote Colorectal Cancer Progression

Advanced Science, EarlyView.
FBXO44 promotes colorectal cancer progression by targeting FOXP1 for ubiquitin‐mediated degradation. This study reveals a phosphorylation‐dependent mechanism involving AURKA and highlights the FBXO44/FOXP1/Cyclin E2 axis as a potential therapeutic target in colorectal cancer.
Hongxu Nie, Hengjie Xu, Sheng Yang, Chuanxin Tian, Tuo Wang, Chi Jin, Zhihao Chen, Xiaowei Wang, Junwei Tang, Yifei Feng, Yueming Sun   +10 more
wiley   +1 more source

Proof-of-concept for an alternative prion detection method utilizing nanoparticle-enhanced, aptamer-template loop-mediated isothermal amplification. [PDF]

Sci Rep
Ramos JH, Matsuoka Y, Sewid AH, Rice JH, Dalrymple DZ, Eda S.   +5 more
europepmc   +1 more source

Transcriptome‐Wide Association Uncovers LncRNAs Controlling Seed Weight in Soybean

Advanced Science, EarlyView.
This study employs transcriptome‐wide association studies (TWAS) to identify 201 long non‐coding RNAs (lncRNAs) associated with seed weight. Expression quantitative trait locus (eQTL) analysis reveals dynamic and static regulatory variants controlling lncRNA expression across development.
Xiang Wang, Xinyu Jiang, Xiaobo Yuan, Zhipeng Zhou, Zhenwei Zhao, Longfei Wang, Wu Jiao, Wenxue Ye, Qingxin Song   +8 more
wiley   +1 more source

Expression of spike and hemagglutinin-esterase proteins is necessary to recover infectious recombinant bovine coronavirus. [PDF]

J Virol
Sugiura Y, Takahashi T, Ueno S, Amarbayasgalan S, Shimizu K, Ujike M, Suzuki T, Kamitani W.   +7 more
europepmc   +1 more source

Emodin Alleviates Sepsis‐Induced Multiorgan Damage by Inhibiting NETosis through Targeting Neutrophils BCL‐10

Advanced Science, EarlyView.
Emodin targets BCL‐10 to modulate the BCL‐10/MALT1 complex, thereby suppressing NF‐κB activation and significantly exerting multiorgan protective effects in sepsis. Abstract Sepsis is a life‐threatening condition caused by dysregulated host responses to infection, characterized by excessive inflammation and abnormal coagulation.
Xiaolong Xu, Yumeng Yan, Meiling Zheng, Mina Zhang, Tengfei Chen, Zhicheng Qu, Yinglu Bai, Shuwen Zhang, Chunming Zhao, Yifan Shi, Yan Lin, Ning Wang, Yunjing Bai, Yating Zhai, Zhaofang Bai, Wei Guo, Qingquan Liu   +16 more
wiley   +1 more source

"Snip, snip, cure"? Philosophical, legal and biomedical perspectives on novel somatic genomic therapies. [PDF]

Med Health Care Philos
Risse J, Pietrek L, Cantz T, Krzemien M, Schnalke J, Eggenschwiler R, Heinemann T, Dederer HG.   +7 more
europepmc   +1 more source

Biotin Production by Using Recombinant DNA Technology

, 1992
Ohji Ifuku, Shinichiro Haze, Jiro Kishimoto, Mitsuo Yanagi   +3 more
openalex   +2 more sources

Exploring Functionally Enhanced BLP‐Trained Macrophage Subpopulations in S. Aureus Infection: Underlying Mechanisms and Therapeutic Significance

Advanced Science, EarlyView.
BLP‐trained macrophages show augmented resistance to infection, but their mechanisms remain unclear. scRNA‐seq identified 13 BMDM subsets, with two novel anti‐inflammatory/antibacterial subpopulations (C5/C7) emerging post‐BLP training. BLP training activates NRF2, attenuates oxidative stress/ferroptosis, and boosts glycolysis/OXPHOS. Adoptive transfer
Yantong Wan, Yinghao Hong, Xiangjun Ji, Jing Xiang, Jinxi Liu, Lixin Liang, Meng Ren, Wenhan Chen, Tengfei Xu, Zhijie Li, Tieliu Shi, Yong Jiang, Huaping Liang, Jinghua Liu   +13 more
wiley   +1 more source

Characterization and antibody preparation of the gene products of grouper iridovirus ORF120L. [PDF]

Virus Res
Cheng CF, Chuang HC, Lai YS.
europepmc   +1 more source

Historical perspectives pertaining to the NIH Recombinant DNA Advisory Committee. [PDF]

Hum Gene Ther, 2014
Wivel NA.
europepmc   +1 more source