Potent Cross‐neutralizing Antibodies Reveal Vulnerabilities of Henipavirus Fusion Glycoprotein
Hendra and Nipah viruses (HNVs) pose significant threats to global health. This work reports potent cross‐neutralizing antibodies targeting the fusion glycoprotein (F) and reveals shared features of these antibodies and vulnerabilities of F, thereby guiding the rational design of countermeasures against HNVs and similar pathogens.
Yi Ren+19 more
wiley +1 more source
Aortic dissection (AD) is accompanied by a decrease in CCDC80 in vascular smooth muscle cells (VSMCs). CCDC80 can interact with JAK2, and VSMC‐specific CCDC80 deficiency accelerates the progression of AD by activating the JAK2/STAT3 pathway involved in regulating the phenotype switching and function of VSMCs.
Qingqing Xiao+18 more
wiley +1 more source
Characterization of glutamine synthetase involved in the fecundity of Rhopalosiphum padi. [PDF]
Li XY, Wang JQ, Zheng KW, Li YT.
europepmc +1 more source
Structure and Antigenicity of Kaposi's Sarcoma‐Associated Herpesvirus Glycoprotein B
Kaposi's sarcoma‐associated herpesvirus (KSHV) causes severe cancers without effective treatments. This study presents an atomic model of KSHV's critical infection protein, gB, revealing a unique structure shared with related herpesviruses like Epstein‐Barr virus (EBV). The structural similarity highlights vulnerable targets for antibodies, guiding the
Xin‐Yan Fang+8 more
wiley +1 more source
Autographa californica multiple nucleopolyhedrovirus Ac51 interacts with Ac66 and facilitates its nuclear localization to promote the nuclear egress of nucleocapsids. [PDF]
Qiu J+10 more
europepmc +1 more source
The release of COL6A3 by fibroblasts is sensed by the CD44 receptor on melanocytes, activating glutathione (GSH) metabolism and increasing melanocyte survival during skin organoid culture. SEMA3C released by bulge cells binds to the NRP1 receptor on melanocytes, regulating microtubule stability and promoting melanocyte recruitment and function during ...
Tingting Li+17 more
wiley +1 more source
Rapid Plasmid-Free Generation of Recombinant Positive-Strand RNA Viruses That Use IRES-Mediated Translation Using an Expansion of the Circular Polymerase Extension Reaction (CPER). [PDF]
Yamamoto H, Tamura T, Fukuhara T.
europepmc +1 more source
Efficient secretory production of recombinant proteins in microalgae using an exogenous signal peptide. [PDF]
Le TT+9 more
europepmc +1 more source
Harnessing Transient Expression Systems with Plant Viral Vectors for the Production of Biopharmaceuticals in <i>Nicotiana benthamiana</i>. [PDF]
Akher SA+6 more
europepmc +1 more source
Isolation, identification, whole genome sequence analysis, and pathogenicity of a potential recombinant goose parvovirus. [PDF]
Zhu Q+15 more
europepmc +1 more source