Results 301 to 310 of about 3,228,085 (398)

Detection of avian infectious bronchitis viral infection using in situ hybridization and recombinant DNA

, 1990
Ellen W. Collisson, Junzhou Li, Loyd Sneed, Mary Lou Peters, Li Wang   +4 more
openalex   +1 more source

Targeted Delivery of α‐ketoglutarate to Macrophages in Bone: A Novel Therapeutic Strategy for Improving Fracture Healing in Type 2 Diabetes

Advanced Science, EarlyView.
The study reveals that glutaminolysis in macrophages is inhibited under type 2 diabetes mellitus (T2DM) conditions, which impedes fracture healing by reducing bone morphogenetic protein 2 (BMP2) production through increased cytosine methylation on the promoter.
Jing Wang, Jiahao Cao, Siqi Zhang, Hongli Chen, Xuebing Yu, Xinli Wang, Tianji Wang, Wei Cao, Wengang Dong, Xinsen Lin, Jia Li, Wei Lei, Yafei Feng   +12 more
wiley   +1 more source

Straightforward MALDI-TOF MS based screening approach for selection of recombinant protein-expressing <i>E. coli</i>. [PDF]

Biotechnol Notes
Kravtsov IN, Solovyev AI, Potemkina EA, Kartashova AV, Dmitrieva MA, Danilova KV, Tutykhina IL, Polyakov NB, Desinov VD, Egorova DA, Gintsburg AL.   +10 more
europepmc   +1 more source

IR783‐Stabilized Nanodrugs Enhance Anticancer Immune Response by Synergizing Oxidation Therapy and Epigenetic Modulation

Advanced Science, EarlyView.
IR783‐stabilized nanodrugs composed of NIR dye IR783, ROS inducer β‐lapachone, and epigenetic modulator CUDC101 are designed for breast cancer immunotherapy. The nanodrugs can not only promote cancer cell apoptosis through HDAC inhibition‐enhanced oxidation therapy but also reshape the immunosuppressive microenvironment, which provides a novel strategy
Jinzhao Liu, Meicen Wu, Qingyang Lyu, Chang Yang, Ni Fan, Kang Chen, Weiping Wang   +6 more
wiley   +1 more source

[A Controversy On Tape: Oral History, Witnesses, and Mythmaking in the American Debate About Genetic Engineering, 1975-1980]. [PDF]

NTM
Leber C.
europepmc   +1 more source

MISP Suppresses Ferroptosis via MST1/2 Kinases to Facilitate YAP Activation in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
This study explores the role of Mitotic Spindle Positioning (MISP) as a key inhibitor of ferroptosis in non‐small cell lung cancer (NSCLC). MISP upregulation in NSCLC tissues leads to ferroptosis resistance, promoting cell proliferation. Mechanistically, MISP suppresses Hippo signaling via MST1/2 kinases, activating YAP and enhancing SLC7A11 expression,
Fuquan Zhang, Bingtao Huang, Yiming Xu, Guohong Cao, Mingjing Shen, Changmin Liu, Judong Luo   +6 more
wiley   +1 more source

An attenuated African swine fever virus expressing the E2 glycoprotein of classical swine fever virus protects pigs against challenge of both viruses. [PDF]

Emerg Microbes Infect
Zhang J, Li F, Chen W, Li Y, Zhang Z, Hua R, Liu R, Zhu Y, Sun E, Qiu H, Bu Z, Zhao D.   +11 more
europepmc   +1 more source

Asprosin‐FABP5 Interaction Modulates Mitochondrial Fatty Acid Oxidation through PPARα Contributing to MASLD Development

Advanced Science, EarlyView.
Aided by FABP5, abnormally elevated asprosin in hepatocytes enters the nucleus, targets and inhibits PPARα binding to the CPT1A promoter, thereby suppressing FAO. Circulating asprosin exacerbates insulin resistance, collectively driving MASLD progression.
Yuan‐Yuan Yu, Min Feng, Yi Chen, Hong‐Lin Jia, Qi Zhang, Ming Tong, Yan‐Xi Li, Yu Zhao, Xin‐Xin Liu, Shi‐Feng Cao, Zheng‐kai Wang, Hou‐wei Li, Xue Liu, Yan Zhang   +13 more
wiley   +1 more source

Paternal Obesity‐Induced H3K27me3 Elevation Leads to MANF‐Mediated Transgenerational Metabolic Dysfunction in Female Offspring

Advanced Science, EarlyView.
Paternal lifestyle and environmental exposures play a critical role in the offspring's health. The present study established a paternal obesity model and demonstrated that elevated H3K27me3 levels in sperm persist through the 8‐cell embryo stage. This epigenetic modification triggers transgenerational decrease of MANF, inducing ER stress and activating
Yajun Shi, Weisheng Li, Xi Yu, Yan Zhao, Dan Zhu, Yueyang Song, Zejun Zhao, Yannan Gu, Bin Wei, Lingjun Li, Dongyi Yu, Pengjie Zhang, Qinqin Gao, Miao Sun   +13 more
wiley   +1 more source

Dual one-step recombinase-aided PCR for rapid detection of Candida in blood. [PDF]

Appl Microbiol Biotechnol
Lyu X, Peng K, Han Z, Li H, Chen X, Gao S, Tie Y, Gao Y, Wang Y, Wang J, Shen X, Ma X, Feng Z.   +12 more
europepmc   +1 more source