Results 51 to 60 of about 13,745 (204)

Thromboembolic Risks of Recombinant Factor VIIa Use in Warfarin-Associated Intracranial Hemorrhage: A Case–Control Study [PDF]

, 2013
Background: Recombinant factor VIIa (rFVIIa) may be used for rapid hemostasis in life-threatening hemorrhage. In warfarin-associated intracerebral hemorrhage (wICH), FVIIa use is controversial and may carry significant thromboembolic risks.
Bresette, Linda M, Cai, Xuemei, Chou, Sherry Hsiang-Yi, Feske, Steven K., Henderson, Galen Vincent, Konigsberg, Rachael G, Sorond, Farzaneh A.   +6 more
core   +1 more source

Oral wound healing in the elderly: Mechanisms, challenges, and innovations

Periodontology 2000, EarlyView.
Abstract Objective This narrative synthesizes current knowledge on the biological mechanisms, clinical challenges, and regenerative innovations for optimizing intraoral wound healing in the elderly. Methods Narrative review of preclinical and clinical studies addressing age‐related changes in the four canonical wound‐healing phases (hemostasis ...
Ann M. Decker, Sandra H. Stuhr, Gustavo Avila‐Ortiz, Andrea Pilloni, Lorenzo Marini, Rogerio Castilho, Beth I. Wallace, Yvonne L. Hernandez‐Kapila   +7 more
wiley   +1 more source

On‐demand treatment of bleeds in haemophilia patients with inhibitors: strategies for securing and maintaining predictable efficacy with recombinant activated factor VII [PDF]

, 2011
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90042/1/j.1365-2516.2011.02612.x ...
Abshire, Abshire, Abshire, Astermark, Berntorp, Beyer, Beyer, Croom, DiMichele, Escobar, Gringeri, Hay, Hay, Hedner, Kavakli, Key, Levi, Lindley, Lusher, Lusher, Lusher, Mathew, Monroe, Nair, Ovanesov, Paisley, Perez Bianco, Pruthi, Salaj, Santagostino, Santagostino, Shapiro, Soucie, Teitel, Tengborn, Valentino, Villar, Young, Young   +38 more
core   +1 more source

Atrophic Skeletal Muscle‐Derived Extracellular Vesicles Transfer miR‐125a‐5p to Inhibit Bone Formation in Osteoporosis during Aging

Advanced Science, Volume 13, Issue 25, 4 May 2026.
A muscle‐bone endocrine pathway in aging is revealed in which extracellular vesicles released from atrophic skeletal muscle (Aged‐SKM‐EVs) inhibit bone formation. These EVs deliver miR‐125a‐5p to osteoblasts, thereby suppressing the SIRT7‐Sp7 signaling axis and osteogenic differentiation.
Xiaoyan Shao, Pan Zhang, Zhidan Fan, Jiaquan Lin, Xiang Chen, Na Liu, Wang Gong, Yi He, Yining Zhou, Tianshu Shi, Yong Shi, Yuze Ma, Wentian Gao, Haosheng Wang, Depeng Fang, Chengzhi Wang, Wenshu Wu, Wenjin Yan, Jianghui Qin, Dongyang Chen, Haiguo Yu, Qing Jiang, Baosheng Guo   +22 more
wiley   +1 more source

Recombinant-activated factor VII in patients with uncontrolled bleeding: A retrospective observational analysis

Asian Journal of Transfusion Science, 2012
Background: Factor VIIa (recombinant) has an off-label use to control life-threatening bleeding that is refractory to other measures and was shown to decrease transfusion requirements.
Said D Abuhasna, Amer H Al Jundi, Hashem A Tarifi   +2 more
doaj   +1 more source

Luteolin Protects Against Noise‐Induced Hearing Loss via Mitigating Oxidative Stress and Apoptosis, With Potential Regulation of the EGR1/SPRY4 Axis

CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.
Luteolin attenuates noise‐induced auditory hair cell loss, as well as TBHP‐induced oxidative stress and apoptosis. EGR1 modulates the transcription of SPRY4; the expression levels of both factors are upregulated following TBHP exposure, and this inductive effect is abrogated by luteolin treatment.
Jia‐ning Guo, Hong‐kai Mei, Rui Liang, Peng‐wei Ma, Wei‐long Wang, Jia‐wei Chen, Zi Wang, Hao Yuan, Yu‐qiang Lun, Wei Gao, Lian‐jun Lu   +10 more
wiley   +1 more source

The use of two novel techniques in the coagulopathic trauma patient in intensive care [PDF]

, 2009
Severe Trauma is a multisystem disorder with a high mortality in an often young population. It offers a big challenge to the intensivist, and any help that is available might prove decisive in saving the patient’s life.
Aquilina, Andrew, Sciberras, Stephen C.
core  

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, Volume 183, Issue 9, Page 1779-1813, May 2026.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

Recent acquisitions in the pathophysiology, diagnosis and treatment of disseminated intravascular coagulation [PDF]

, 2006
Disseminated intravascular coagulation (DIC) is a disorder characterized by both acute generalized, widespread activation of coagulation, which results in thrombotic complications due to the intravascular formation of fibrin, and diffuse hemorrhages, due
Lippi Giuseppe, Franchini Massimo, Manzato Franco   +2 more
core   +2 more sources

A Specific Sinorhizobium Flagellin Suppresses Legume Nodulation Through Immune Activation

Plant Biotechnology Journal, Volume 24, Issue 5, Page 3441-3457, May 2026.
ABSTRACT Bacterial flagellin‐activated immunity plays a crucial role in shaping plant‐microbe interactions, leading to either parasitism, mutualism, or commensalism. In the legume‐rhizobium symbiosis, while it has been hypothesized that rhizobial infection involves avoidance of plant immunity following flagellin perception, direct evidence supporting ...
Li Liu, Yaohua Li, Shuangcheng Ye, Chuanzheng Wei, Ziang Yan, Huanhui Yang, Hui Zhu, Gary Stacey, Yangrong Cao   +8 more
wiley   +1 more source