Results 211 to 220 of about 282,766 (336)

Solid-State Nuclear Magnetic Resonance (NMR) Spectroscopy of Human Immunodeficiency Virus gp41 Protein That Includes the Fusion Peptide: NMR Detection of Recombinant Fgp41 in Inclusion Bodies in Whole Bacterial Cells and Structural Characterization of Purified and Membrane-Associated Fgp41 [PDF]

, 2011
Erica P. Vogel, Jaime Curtis-Fisk, Kaitlin M. Young, David P. Weliky   +3 more
openalex   +1 more source

Dual‐Locking the SARS‐CoV‐2 Spike Trimer: An Amphipathic Molecular “Bolt” Stabilizes Conserved Druggable Interfaces for Coronavirus Inhibition

Advanced Science, EarlyView.
A new amphipathic molecule, S416 is discovered, that locks the SARS‐CoV‐2 spike protein in its closed state, blocking viral entry. S416 acts as a molecular bolt, binding six sites: three between adjacent RBDs and three connecting NTDs to RBDs. This dual‐locking mechanism stiffens the spike structure and reduces its flexibility.
Shiliang Li, Fang Ye, Yucheng Zheng, Jie Wang, Haoran Peng, Lili Zhu, Lili Chen, Tao Yu, Huan Ge, Jiaqi He, Binghao Zhang, Jiayun Wu, Zhiyi Zhang, Liangliang Jiang, Geng Chen, Ping Zhao, Ke Lan, Zhenjiang Zhao, Xuhong Qian, Ke Xu, Yang Du, Honglin Li   +21 more
wiley   +1 more source

Construction of Tandem Multimers with Different Combinatorial Forms of BmSPI38 and BmSPI39 and Analysis of Their Expression and Activity in <i>Escherichia coli</i>. [PDF]

Int J Mol Sci
Zhang Z, Li Y, Yang X, Chen C, Ru S, Jiang J, Cai W, Li J, Du J, Qiao D.   +9 more
europepmc   +1 more source

pC6-2/caspase-6 system to purify glutathione-S-transferase-free recombinant fusion proteins expressed in Escherichia coli

, 2006
Prabhat Kumar Purbey, P. Cyril Jayakumar, Milind S. Patole, Sanjeev Galande   +3 more
openalex   +1 more source

Recombinant TAT-CD137 Ligand Cytoplasmic Domain Fusion Protein Induces the Production of IL-6 and TNF-α in Peritoneal Macrophages [PDF]

, 2011
Jung Dae Kim, Eun Ah Lee, Nguyen N. Quang, Hong Rae Cho, Byungsuk Kwon   +4 more
openalex   +1 more source

Unveiling Salt Tolerance Mechanisms in Plants: Integrating the KANMB Machine Learning Model With Metabolomic and Transcriptomic Analysis

Advanced Science, EarlyView.
Salt stress endangers coastal cereal crops, requiring resilient crop solutions. This study employs machine learning (KANMB) to analyze multi‐omics data from halophyte Spartina alterniflora, revealing 226 salt‐stress biomarkers and linking them to tolerance pathways. The MYB gene SaMYB35 regulates flavonoid biosynthesis under salinity.
Shoukun Chen, Hao Zhang, Shuqiang Gao, Kunhui He, Tingxi Yu, Shang Gao, Jiankang Wang, Huihui Li   +7 more
wiley   +1 more source

An engineered PD1-Fc fusion produced in N. benthamiana plants efficiently blocks PD1/PDL1 interaction. [PDF]

Plant Cell Rep
Izadi S, Abrantes R, Gumpelmair S, Kunnummel V, Duarte HO, Steinberger P, Reis CA, Castilho A.   +7 more
europepmc   +1 more source

Specific and efficient cleavage of fusion proteins by recombinant plum pox virus NIa protease

, 2007
Nuoyan Zheng, José de Jesús Pérez, Zhonghui Zhang, Elvira Domı́nguez, Juan Antonio Garcı́a, Qi Xie   +5 more
openalex   +1 more source

LncRNA‐MEG3 Regulates Muscle Mass and Metabolic Homeostasis by Facilitating SUZ12 Liquid–Liquid Phase Separation

Advanced Science, EarlyView.
This study has identified lncRNA‐MEG3 as a key regulator of muscle mass, promoting slow‐twitch muscle fibers and preventing muscle atrophy. By stabilizing the SUZ12/PRC2 complex through liquid–liquid phase separation (LLPS), lncRNA‐MEG3 influences mitochondrial function and lipid metabolism.
Yilong Yao, Chao Yan, Haibo Huang, Shilong Wang, Jiaying Li, Yun Chen, Xiaolu Qu, Qi Bao, Lingna Xu, Yuanyuan Zhang, Danyang Fan, Xia He, Yanwen Liu, Yongsheng Zhang, Yalan Yang, Zhonglin Tang   +15 more
wiley   +1 more source

Incorporation of recombinant proteins into extracellular vesicles by Lactococcus cremoris. [PDF]

Sci Rep
Plavec TV, Žagar Soderžnik K, Della Pelle G, Zupančič Š, Vidmar R, Berlec A.   +5 more
europepmc   +1 more source