Results 231 to 240 of about 399,275 (342)

Extracellular Vesicle‐Delivered tRF‐His‐GTG‐1 Reprograms Neutrophil Lipophagy and Triggers Inflammation in COVID‐19

Advanced Science, EarlyView.
This study identifies platelet‐derived extracellular vesicles as key immunometabolic regulators in COVID‐19. The delivery of tRF‐His‐GTG‐1 to neutrophils activates TLR8mTOR signaling, disrupts lipophagy, and amplifies NET‐mediated inflammation. Importantly, targeting this axis restores neutrophil homeostasis, offering a potential therapeutic strategy ...
Tsai‐Ling Liao, Po‐Yu Liu, Yi‐Ming Chen, Kuo‐Tung Tang, Hung‐Jen Liu, Der‐Yuan Chen   +5 more
wiley   +1 more source

Recombinant G-CSF-ApoAI Fusion Protein Is a Pleiotropic Factor. [PDF]

Molecules
Miroshnichenko S, Pykhtina M, Mosalev K, Beklemishev A.   +3 more
europepmc   +1 more source

Supplementary Material for: Expression and Purification of Recombinant Human Basic Fibroblast Growth Factor Fusion Proteins and Their Uses in Human Stem Cell Culture

, 2015
Sumeth Imsoonthornruksa, Kamthorn Pruksananonda, Rangsun Parnpai, Ruttachuk Rungsiwiwut, Mariena Ketudat‐Cairns   +4 more
openalex   +1 more source

Pharmacokinetics and pharmacodynamics of a recombinant fusion protein linking activated coagulation factor VII with human albumin (rVIIa-FP) in patients with congenital FVII deficiency [PDF]

, 2019
Britta Laros‐van Gorkom, Pål André Holme, Christine Joch, Tobias Rogosch, Annette Feussner, William McKeand, John Roberts, Waander L. van Heerde   +7 more
openalex   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Development of Norrin-Based Protein Therapeutic for Activation of Norrin-Wnt Signaling in Human Retinal Endothelial Cells. [PDF]

Int J Mol Sci
Mitton KP, Dailey WA, Krikor SQ, Drenser KA.   +3 more
europepmc   +1 more source

Vaccine Based on Recombinant Fusion Protein Combining HBV PreS with SARS-CoV-2 Wild-Type- and Omicron-Derived RBD Strongly Induces Omicron-Neutralizing Antibodies

Pia Gattinger, Bernhard Kratzer, Al Nasar Ahmed Sehgal, Anna Ohradanova‐Repic, Laura Gebetsberger, Gábor Tajti, Margarete Focke‐Tejkl, Mirjam Schaar, Verena Fuhrmann, Lukas Petrowitsch, Walter Keller, Sandra Högler, Hannes Stockinger, Winfried F. Pickl, Rudolf Valenta   +14 more
openalex   +2 more sources

Recombinant feline corona virus-S protein; expressed as galactokinase fusion protein and useful as reconbinant vaccine, therapeutic and diagnostic agents for feline-infectious-peritonitis virus

, 1992

openalex   +2 more sources

Safety and prolonged activity of recombinant factor VIII Fc fusion protein in hemophilia A patients [PDF]

, 2012
Jerry S. Powell, Neil C. Josephson, Doris Quon, Margaret V. Ragni, Gregory Cheng, Ella Li, Haiyan Jiang, Lian Li, Jennifer Dumont, Jaya Goyal, Xin Zhang, Jürg M. Sommer, Justin T. McCue, Margaret Barbetti, Alvin Luk, Glenn F. Pierce   +15 more
openalex   +1 more source

ZNRD2 Mediated Nucleoprotein Aggregation Impairs Respiratory Syncytial Virus Replication

Advanced Science, EarlyView.
During RSV infection, nucleoprotein (N) forms RNA‐bound oligomers. The host protein ZNRD2 binds to these oligomers, promoting their transition into insoluble aggregates. These aggregates simultaneously sequester functional N to restrict viral production and disrupt chaperonin assembly quality control by interfering with ZNRD2's role as an adaptor ...
Haiwu Zhou, Mingbin He, Jinhong Du, Cong Liu, Weiwei Wang, Yuewen Han, Zhifei Li, Yali Qin, Mingzhou Chen   +8 more
wiley   +1 more source