Results 131 to 140 of about 15,000 (182)

The production of recombinant human erythropoietin

1995
Erythropoietin (EPO) is the glycoprotein hormone that promotes differentiation of erythroid progenitor cells in bone marrow. The normal kidney produces EPO to maintain erythrocyte for oxygen supply. This hormone activity was found in the serum of anemic animals in the 1890s.
N, Inoue, M, Takeuchi, H, Ohashi, T, Suzuki   +3 more
openaire   +2 more sources

Multicenter Study with Recombinant Human Erythropoietin

Artificial Organs, 1993
Abstract: A multicenter study with recombinant human erythropoietin (rh‐EPO) was carried out. Of 172 hemodialysis patients with anemia selected for the study from 20 hospitals and clinics, 77 were males and 95 females (mean age 53.9 years). A starting dose of 1,500 U of rh‐EPO (Epoetin β) was administered intravenously at the end of every dialysis ...
H, Tanaka, E, Kan, Y, Takegaki, H, Inariba, M, Yoshimoto, Y, Ohno, M, Maekawa, N, Tatsumi, T, Kishimoto   +8 more
openaire   +2 more sources

Chromatographic purification of recombinant human erythropoietin

Biotechnology Letters, 2019
Recombinant human erythropoietin is a valuable therapeutic protein used in the treatment of several serious diseases. It exists in different isoforms and is produced by genetically modified mammalian cells such as Chinese hamster ovary or human embryonic kidney cells.
Jana Adamíková, Monika Antošová, Milan Polakovič   +2 more
openaire   +2 more sources

Erythrocytes as Carriers for Recombinant Human Erythropoietin

Pharmaceutical Research, 1996
The aim of this work was to encapsulate recombinant human erythropoietin (rHuEpo) in human and mouse red blood cells (RBCs) to improve the stability of encapsulated rHuEpo.The encapsulation of rHuEpo was achieved by an hypotonic dialysis-isotonic resealing procedure. A radioimmunoassay method was used for the estimation of rHuEpo.
M I, Garín, R M, López, S, Sanz, M, Pinilla, J, Luque   +4 more
openaire   +2 more sources

Recombinant Human Erythropoietin: Implications for Nephrology

American Journal of Kidney Diseases, 1988
The pathophysiology of the anemia of chronic renal failure (CRF), erythropoietin physiology, the characteristics of recombinant human erythropoietin, and the results of nearly 2 years of therapy with this product in hemodialysis patients are detailed in this review.
J W, Eschbach, J W, Adamson
openaire   +2 more sources

Recombinant human erythropoietin and overall survival

Current Oncology Reports, 2005
Although a trend was seen for increased thromboembolic events in patients treated with erythropoietin, there was also a trend for improved survival times in such patients.
openaire   +2 more sources

The Cloning and Production of Recombinant Human Erythropoietin

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 1990
The production of recombinant human erythropoietin (r‐HuEPO) began with a search for the gene coding for human erythropoietin (EPO). Two radiolabeled pools of oligonucleotide probes were designed, based on amino acid sequence information obtained from human urinary EPO. Each probe, consisting of complex mixtures of 128 short synthetic sequences of DNA,
openaire   +2 more sources

Recombinant human erythropoietins, biosimilars and immunogenicity

Journal of Nephrology, 2008
Abstract Biopharmaceutical agents have revolutionised the treatment and management of medical conditions such as diabetes, Gaucher disease, cancer and infertility. From the introduction of the first products of nonhuman origin some 100 years ago, to the more recent addition within the last 2 decades of human recombinant DNA products ...
openaire   +2 more sources

Recombinant Human Erythropoietin in Neonatal Anemia

Clinics in Perinatology, 1995
Recombinant human erythropoietin (r-HuEPO) is a new therapeutic modality for the treatment of neonatal anemia. The results of three large controlled trials were published within the past year. This article reviews the physiologic rationale underlying the use of r-HuEPO in preterm infants, addresses how the design of clinical trials affects outcomes and
openaire   +2 more sources

Metabolism of Recombinant Human Erythropoietin in the Rat

1989
Erythropoietin is the only hematopoietic growth factor which behaves like a hormone. Produced primarily in the kidneys and to a small extent in the liver, erythropoietin interacts with primitive erythroid progenitor cells in the bone marrow. Under normal circumstances, the plasma concentracentration of erythropoietin is maintained within narrow limits ...
openaire   +2 more sources