Results 181 to 190 of about 171,370 (219)

ADA2-Functionalized OMVs Remodel the Tumor Microenvironment in Pancreatic Cancer. [PDF]

Pharmaceutics
Khalaj V, Waller AM, Demmel MV, Sardarni UK, Adams JT, Collier A, Zaske AM, Momeny M, Bailey-Lundberg JM, Azhdarinia A.   +9 more
europepmc   +1 more source

AARS1‐Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer

Advanced Science, EarlyView.
AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Qin Yuan, Tianbao Song, Yipeng He, Sihan Xia, Yaoqiu Huang, Wenlin He, Qin Yi, Zefeng Wang, Peihan Wang, Chenbo Huang, Linzhi Li, Zhen Yin, Fan Cheng, Weimin Yu   +13 more
wiley   +1 more source

Deubiquitination of Vangl by USP6 and USP32 Regulates Planar Cell Polarity Signaling

Advanced Science, EarlyView.
Compartment‐specific deubiquitination controls Vangl dosage and planar cell polarity signaling. USP6 and USP32 regulate distinct subcellular pools of Vangl by removing distinct ubiquitin modifications from Vangl proteins. This regulatory mechanism safeguards PCP‐dependent embryonic morphogenesis, while aberrant USP32‐dependent stabilization of VANGL ...
Fangzi Zha, Di Feng, Ziru Xue, Zhiying Liu, Xiaochen Lin, Zhe Wang, Ling Xu, Jasper Fuk Woo Chan, Martin Cheung, Michael Shing Yan Huen, Yusong Guo, Kui Ming Chan, Yun Liu, Bo Gao   +13 more
wiley   +1 more source

Pilot-Scale Downstream Processing of Recombinant Influenza Virus Vectors Expressing <i>Brucella</i> spp. Antigens Using an Integrated Membrane-Chromatography Purification Platform. [PDF]

Vaccines (Basel)
Assanzhanova N, Sagymbayeva A, Shynybekova G, Shorayeva K, Ryskeldinova S, Mailybayeva A, Myrzakhmetov Y, Yamanova E, Sidikhov R, Almezhanova M, Zhaksylyk S, Absatova Z, Zhugunissov K, Chervyakova O, Akmyrzayev N.   +14 more
europepmc   +1 more source

AHR‐Responsive Carbon Dots Orchestrate Skin Wound Healing and Colonic Mucosal Repair via Treg‐Mediated Macrophage Efferocytosis

Advanced Science, EarlyView.
Guided by pharmacophore modeling and molecular docking, aryl hydrocarbon receptor (AHR)‐responsive carbon dots were synthesized. They bind directly to AHR and expand gut‐resident regulatory T (Treg) cells. Treg‐derived C‐C motif chemokine ligand 1 (CCL1) enhances macrophage efferocytosis, creating a pro‐regenetative niche that promotes colonic mucosal ...
Zilu Zhu, Han Zhang, Shuai Lin, Wenqian Zheng, Xin Li, Xiaowei Xu, Ruili Yang   +6 more
wiley   +1 more source

Generation and Characterization of Single-Domain Antibodies Against the D-Antigen of Sabin Poliovirus Types 2 and 3. [PDF]

Viruses
Ermakova M, Ivanov S, Shmeleva O, Borisenko N, Zyrina A, Levin I, Chumakov S, Shishova A, Ivin Y, Piniaeva A, Siniugina A, Ishmukhametov A.   +11 more
europepmc   +1 more source

Targeting LDHA Palmitoylation Sensitizes GBM to Chemoradiotherapy via Suppressing Palmitic Acid Induced Glycolytic Reprogramming

Advanced Science, EarlyView.
Mesenchymal GSCs preferentially uptake palmitic acid, thereby promoting ZDHHC12‐mediated LDHA palmitoylation. This modification enhances LDHA enzymatic activity, drives glycolytic reprogramming, and facilitates exosomal LDHA‐mediated TAM regulation.
Zijie Gao, Rongrong Zhao, Zheyuan Chen, Qingtong Wang, Huanyu Yang, Boyan Li, Yanhua Qi, Shulin Zhao, Jixing Zhao, Jiawei Qiu, Ziwen Pan, Zhe Han, Ruochuan Li, Huize Xia, Weijie Tang, Xing Guo, Ping Zhang, Hongyu Zhao, Xu Qian, Gang Li, Hao Xue   +20 more
wiley   +1 more source

Targeting the KAT7/H3K14ac/RAC2 Axis Mediates OXPHOS to Promote Stemness Maintenance and Malignancy in Glioblastoma

Advanced Science, EarlyView.
SOX2 upregulates KAT7 in glioma stem cells, where KAT7 deposits H3K14 acetylation at the RAC2 promoter to activate RAC2 transcription. RAC2‐GTP subsequently promotes PAK1/2/3 phosphorylation, increasing tricarboxylic acid cycle flux and mitochondrial respiration to support glioblastoma malignancy.
Jilong Liu, Yanfei Sun, Yuehua Zhu, Guangjing Mu, Jiazheng Wang, Liangliang Wang, Feihu Zhao, Zhimin Zhao, Jian Wang, Ying He, Zheng Jiang, Xingang Li, Mingzhi Han, Bin Huang   +13 more
wiley   +1 more source

Porcine Adenovirus-Based Viral Vectors for Swine Vaccines: A Scoping Review and Future Perspectives. [PDF]

Animals (Basel)
Sthitmatee N, Suanpat K, Sington Y, Muenthaisong A, Sangkakam K, Nambooppha B, Rittipornlertrak A, Apinda N, Koonyosying P, Varinrak T, Kreausukon K.   +10 more
europepmc   +1 more source

Identification of efficient multi-epitope combinations against African swine fever virus based on AP205 scaffold-mediated nanodisplay technology. [PDF]

J Nanobiotechnology
Lu H, Shao J, Liu W, Gao S, Guo H, Dong H, Zhou T, Yang J, Chang H.   +8 more
europepmc   +1 more source