Results 51 to 60 of about 10,600 (216)

PD‐L1‐Binding Antigen Presenters: Redirecting Vaccine‐Induced Antibodies for Cancer Immunotherapy

Advanced Science, EarlyView.
The PBAP‐gE complex anchors gE antigen to PD‐L1 on tumor cells. Vaccine‐induced anti‐gE antibodies simultaneously engage FcγRIIIa on NK cells and tumor‐bound PBAP‐gE, triggering NK cell activation and antibody‐dependent cellular cytotoxicity, thereby selectively eliminating PD‐L1–expressing tumor cells.
Huixin Gao, Lijuan Lu, Xiaoxiao Xiong, Yi Li, Donghui Hu, Duo Zhang, Zhiwei Feng, Cong Liu, Nannan Liu, Xiaoli Li, Jizhou Tan, Ting Liu, Ling Peng, Lu Lu, Huiyi Feng, Yan Zhong, Guisen Tan, Zhicheng Zhang, Liqin Huang, Chao Su, Ying Xue, Shuo Song, Wenxia Fan, Wei Wang, Fan Zou   +24 more
wiley   +1 more source

Development of Novel Immunoassays for Varicella Zoster Virus (VZV) Vaccine and Preliminary Study on Functional Domain of ORF7 protein [PDF]

, 2016
水痘-带状疱疹病毒(Varicella-ZosterVirus，VZV)是水痘和带状疱疹的病原体。VZV具有高度传染性，初次感染可引发水痘，并可潜伏于患者背根神经节，在年老或免疫力低下时可能激活导致带状疱疹，具有严重的危害性。接种疫苗是预防VZV感染的有效方式，但目前使用的VZV减毒活疫苗株v-Oka仍具有感染和潜伏人神经系统的能力，安全隐患不容忽视，因此，亟需研制更为安全有效的新型疫苗。高效、精确的免疫分析技术体系是研制新型疫苗的重要基础。VZV是一种基因组约125Kb，拥有70个ORF ...
刘剑
core  

A Broad Safety Assessment of the Recombinant Herpes Zoster Vaccine

American Journal of Epidemiology, 2022
Abstract The recombinant herpes zoster vaccine (RZV), approved as a 2-dose series in the United States in October 2017, has proven highly effective and generally safe. However, a small risk of Guillain-Barré syndrome after vaccination was identified after approval, and questions remain about other possible adverse events.
Yih, W Katherine, Kulldorff, Martin, Dashevsky, Inna, Maro, Judith C   +3 more
openaire   +2 more sources

Fatal Chronic Varicella‐Zoster Viral Infection in a Young Man With Chediak–Higashi Syndrome

Pediatric Dermatology, EarlyView.
ABSTRACT Chediak–Higashi syndrome (CHS) is a rare autosomal recessive primary immunodeficiency characterized by partial oculocutaneous albinism, neurologic involvement, and a predisposition to severe infections. Patients are particularly susceptible to developing hemophagocytic lymphohistiocytosis (HLH), which significantly worsens prognosis. We report
Albane Badet, Clément Pruvot, Zoé Manssens, Wadih Abou‐Chahla, Sébastien Buche   +4 more
wiley   +1 more source

IFN-α armed gE elicits superior immunogenicity compared to unmodified antigens and flagellin armed gE in mice

Vaccine: X
Herpes zoster (HZ) induces significant pain and discomfort, which can seriously affect the quality of life of patients. At present, there is no specific treatment for HZ, and the mosteffective HZ control is vaccination. The main obstacle to developing an
Jiangang Zhang, Shaodan Peng, Fang Xu, Ying Qiao, Xiaoke Ye, Yu Guan, Xiaolong Zhao, Yueran Wang, Zhongqi Shao, Tao Zhu, Weixue Si   +10 more
doaj   +1 more source

Advances in understanding the mechanism of action of adult vaccines

The Journal of Clinical Investigation, 2023
The occurrence of herpes zoster (HZ) correlates with declining memory T cells that had responded to earlier infection with varicella-zoster virus (VZV).
Anthony L. Cunningham, Kerrie J. Sandgren, Naomi R. Truong   +2 more
doaj   +1 more source

Development of antibody-dependent cellular cytotoxicity in response to recombinant and live-attenuated herpes zoster vaccines

npj Vaccines, 2022
Zoster vaccines generate antibody responses against varicella-zoster virus (VZV). We compared antibody-dependent cell cytotoxicity (ADCC) elicited by zoster vaccine live (ZVL) and recombinant zoster vaccine (RZV).
Seong Yeon Park, Myron J. Levin, Jennifer Canniff, Michael Johnson, D. Scott Schmid, Adriana Weinberg   +5 more
doaj   +1 more source

Recombinant Zoster Vaccine Is Efficacious and Safe in Frail Individuals [PDF]

Journal of the American Geriatrics Society, 2020
BACKGROUND/OBJECTIVES Frail participants are often under‐represented in randomized trials, raising questions about outcomes of interventions in real‐world settings. Frailty is strongly associated with vulnerability to illness and adverse health outcomes.
Desmond Curran, Joon H. Kim, Sean Matthews, Christophe Dessart, Myron J. Levin, Lidia Oostvogels, Megan E. Riley, Kenneth E. Schmader, Anthony L. Cunningham, Shelly A. McNeil, Anne E. Schuind, Melissa K. Andrew   +11 more
openaire   +2 more sources

Infections in Chronic Lymphocytic Leukemia: Evolving Risks and Prevention Strategies

European Journal of Haematology, Volume 116, Issue 3, Page 204-214, March 2026.
ABSTRACT Infections remain a leading cause of morbidity and mortality in patients with chronic lymphocytic leukemia (CLL), reflecting both intrinsic immune dysfunction and therapy‐related immunosuppression. The pathogenesis of immunodeficiency in CLL is multifactorial: neoplastic B cells impair humoral immunity, T cells are functionally exhausted, and ...
Enrica Antonia Martino, Santino Caserta, Ernesto Vigna, Antonella Bruzzese, Nicola Amodio, Eugenio Lucia, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Fortunato Morabito, Massimo Gentile   +10 more
wiley   +1 more source

A spliced latency-associated VZV transcript maps antisense to the viral transactivator gene [PDF]

, 2018
Varicella-zoster virus (VZV), an alphaherpesvirus, establishes lifelong latent infection in the neurons of >90% humans worldwide, reactivating in one-third to cause shingles, debilitating pain and stroke. How VZV maintains latency remains unclear.
Braspenning, S.E. (Shirley E.), Breuer, J. (Judith), Cohrs, R.J. (Randall ), Depledge, D.P. (Daniel P.), Mori, Y. (Yasuko), Ouwendijk, W.J.D. (Werner), Sadaoka, T. (Tomohiko), Verjans, G.M.G.M. (George)   +7 more
core   +6 more sources