Results 111 to 120 of about 36,229 (210)

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, Volume 36, Issue 36, 4 May 2026.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Application and research progress of recombinase isothermal amplification technology in the analysis of animal and plant components

Zhongguo shipin weisheng zazhi
Recently， the analysis of animal- and plant-derived components， mainly based on the adulteration and smuggling of meat products and genetically modified crops， has been a key focus in the field of food safety.
SHI Yunxue, WANG Xin, WANG Jun, YAO Hua, WU Yu   +4 more
doaj   +1 more source

Stress-resistant plants and their production [PDF]

, 2012
The present invention relates to plant genes involved in negative regulation of resistance to biotic and/or abiotic stress and uses thereof. More particularly, the present invention relates to plants comprising an inactivated MADS-box gene function, and ...
Gantet, Pascal, Guiderdoni, Emmanuel, Khong, Ngan Giang, Morel, Jean-Benoit   +3 more
core  

Evidence of Mycobacterium tuberculosis Complex bacteraemia in intradermal skin test positive cattle detected using phage-RPA [PDF]

, 2016
Bovine tuberculosis is a zoonotic infectious disease caused by Mycobacterium bovis 19 that affects cattle and can cause tuberculosis in a range of wildlife animals.
Albert H, Albert H, David ST, Katoch VM, Srivastava K   +4 more
core   +2 more sources

Liver Stiffness Directs Intrahepatic Cholesterol Accumulation Through YAP/TAZ in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, Volume 13, Issue 25, 4 May 2026.
Liver stiffness promotes intrahepatic cholesterol accumulation by repressing LXRα through YAP/TAZ activation. Stiff matrices impair cholesterol efflux in hepatocytes, while YAP/TAZ deletion restores LXRα activity and prevents cholesterol‐induced fibrosis.
Na Young Lee, Myeung Gi Choi, Ho Jae Ryu, Young Jin Min, Seon Min Kim, Yeonseok Chung, Bo Kyung Koo, Yun Pyo Kang, Won Kim, Ja Hyun Koo   +9 more
wiley   +1 more source

Digital Isothermal Quantification of Nucleic Acids via Simultaneous Chemical Initiation of Recombinase Polymerase Amplification Reactions on SlipChip [PDF]

, 2011
In this paper, digital quantitative detection of nucleic acids was achieved at the single-molecule level by chemical initiation of over one thousand sequence-specific, nanoliter isothermal amplification reactions in parallel.
Davydova, Elena K., Du, Wenbin, Ismagilov, Rustem F., Kreutz, Jason E., Piepenburg, Olaf, Shen, Feng   +5 more
core   +2 more sources

A single JAK2‐V617F hematopoietic stem cell can initiate myeloproliferative neoplasm when transplanted into non‐conditioned recipient mice

HemaSphere, Volume 10, Issue 5, May 2026.
Abstract Myeloproliferative neoplasms (MPNs) are clonal disorders of hematopoietic stem cells (HSCs) that are most frequently caused by acquired somatic mutations in JAK2. A number of conditional mouse models of JAK2‐V617F‐driven MPN have been generated that rely on Cre‐LoxP‐mediated activation, resulting in polyclonal disease.
Quentin Kimmerlin, Morgane Hilpert, Nils Hansen, Alexandre Guy, Marc Usart, Jan Stetka, Patryk Sobieralski, Tiago Almeida Fonseca, Hui Hao‐Shen, Radek C. Skoda   +9 more
wiley   +1 more source

Transcription factor Sp2: Molecular characterization and generation of Sp2 gene targeted mice [PDF]

, 2005
Summary The Sp family of transcription factors is characterised by its DNA-binding domain, an array of three conserved C2H2 zinc fingers. As a consequence of the conserved DNA binding motif, Sp members recognize GC (GGGGCGGGG) and GT (GGTGTGGGG) boxes
Baur, Frank, Renkawitz-Pohl, Renate (Prof. Dr.)   +1 more
core   +1 more source

RPA Combined With CRISPR/Cas12a for Rapid and Ultrasensitive Detection Dual‐Gene of Methicillin‐Resistant Staphylococcus aureus (MRSA)

Journal of Molecular Recognition, Volume 39, Issue 3, May 2026.
ABSTRACT The increasing issue of infections caused by methicillin‐resistant Staphylococcus aureus (MRSA) necessitates rapid and reliable diagnostic methods. While existing RPA‐CRISPR/Cas12a platforms have demonstrated potential for MRSA detection, most rely on single‐gene targets or require multiple Cas enzymes.
Lei Chen, Jun Luo, Helin Zhang, Pingsen Zhao   +3 more
wiley   +1 more source

TFIIIC Localizes Budding Yeast ETC Sites to the Nuclear Periphery [PDF]

, 2012
Peer reviewedPublisher ...
Botsios, Sotirios, Donaldson, Anne Dunlop, Donze, David, Hiraga, Shinichiro   +3 more
core   +2 more sources