Results 91 to 100 of about 1,237,966 (248)
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Deep Learning in Music Recommendation Systems
Frontiers in Applied Mathematics and Statistics, 2019 Like in many other research areas, deep learning (DL) is increasingly adopted in music recommendation systems (MRS). Deep neural networks are used in this domain particularly for extracting latent factors of music items from audio signals or metadata and
Markus Schedl
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Comparative Study of Filtering Methods for Scientific Research Article Recommendations
Big Data and Cognitive ComputingGiven the daily influx of scientific publications, researchers often face challenges in identifying relevant content amid the vast volume of available information, typically resorting to conventional methods like keyword searches or manual browsing ...
Driss El Alaoui +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
From Data to Decisions: The Power of Machine Learning in Business Recommendations
IEEE AccessThis research aims to explore the impact of machine learning (ML) on the evolution and efficacy of recommendation systems (RS), particularly in the context of their growing significance in commercial business environments.
Kapilya Gangadharan +5 more
doaj +1 more source
A Comparative Study of Rank Aggregation Methods in Recommendation Systems. [PDF]
Entropy (Basel), 2023 Bałchanowski M, Boryczka U.
europepmc +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Scientific paper recommendation systems: a literature review of recent publications. [PDF]
Int J Digit Libr, 2022 Kreutz CK, Schenkel R.
europepmc +1 more source