Results 101 to 110 of about 25,123 (277)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

A Recommender System based on the Immune Network [PDF]

, 2008
Steve Cazyer, Uwe Aickelin
openalex   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

KT-CDULF: Knowledge Transfer in Context-Aware Cross-Domain Recommender Systems via Latent User Profiling

IEEE Access
Recommender systems are crucial in today’s digital world, by enhancing user engagement experience in digital ecosystems. Internet of things (IoT) have huge potential to generate dynamic and real time data.
Adeel Ashraf Cheema, Muhammad Shahzad Sarfraz, Muhammad Usman, Qamar Uz Zaman, Usman Habib, Ekkarat Boonchieng   +5 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

A Comprehensive Review of Recommender Systems in the Cultural Sector

Journal of Information Sciences
One of the most essential aspects of human life is culture since it plays a crucial role in shaping their identity and worldview. The need for effective cultural recommender systems increases as globalization expands and the cultural products become more
IMAD EL-ATTAR, Lamia BENAMEUR, Mohamed CHRAYAH   +2 more
doaj   +1 more source

Web-Based Recommender System for High School Major Decision Using Forward Chaining

, 2022
Ira Wardani, Prima Dina Atika, Herlawati Herlawati   +2 more
openalex   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

An Interactive System for Capturing Users’ Qualitative Preferences in Recommender Systems

, 2022
Kushal Dave, Malek Mouhoub
openalex   +1 more source

Exploring chemical compound space with a graph-based recommender system [PDF]

, 2023
Elton Ogoshi, Henrique Bunselmeyer Ferreira, J. N. B. Rodrigues, Gustavo M. Dalpian   +3 more
openalex   +1 more source