Results 191 to 200 of about 22,424 (258)

Stepwise Evolution of Immunodeficient Mouse Models: Focus on NCG Strains and Their Applications in Humanized Immune System Research. [PDF]

Vaccines (Basel)
Sun H, Fan J, Zhang Y, Xing J, Zhang Y, Ju C, Liang J.   +6 more
europepmc   +1 more source

An IscS Persulfide Donates the Sulfur for Ribosomal Protein uL16 Thioamidation

Angewandte Chemie, EarlyView.
YcaO‐catalyzed thioamidation of the ribosomal subunit protein uL16 is widespread in Pseudomonadota bacteria. We identify the iron–sulfur cluster cysteine desulfurase IscS as the sulfur donor via an IscS persulfide and observe direct IscS–uL16 interactions.
Yanqing Xue, Markus W. Voehler, Douglas A. Mitchell   +2 more
wiley   +1 more source

Beyond Pandemic Preparedness: Reframing Protracted War Against Infectious Diseases. [PDF]

Viruses
Zheng M.
europepmc   +1 more source

Differential Water Networks Guide Selectivity Optimization of a Cell Active BPTF Inhibitor in Neuroblastoma

Angewandte Chemie, EarlyView.
BZ2 is a second‐generation Bromodomain PHD finger Transcription Factor (BPTF) inhibitor with improved selectivity over Class I and Class IV BRD off‐targets identified in our previously reported inhibitor, BZ1. Structural analyses reveal that water network engagement is key to this selectivity.
Kesavan Babu, Chun‐Ju Tsou, Sourav Das, Liying Fan, Anasuya Pal, Molly Sneddon, Timothy R. Stachowski, Priyanka Samanta, Stanley Nithianantham, Caroline Buchholz, Shi Zhang, Xiang Fu, Rahul S. Kathayat, Wenwei Lin, Yongtao Li, Lei Yang, Taosheng Chen, Marcus Fischer, Anang A. Shelat, William C. K. Pomerantz   +19 more
wiley   +1 more source

The Venom Proteome and Immunorecognition Profile of Clinically Important <i>Echis carinatus sochureki</i> from Northwestern India Underscores the Need for Regionally Specific Antivenoms. [PDF]

Toxins (Basel)
Kumar A, Sahu A, Gopalakrishnan M, Blotra A, Rout VK, Kuttalam S, Muralidar S, Malhotra A, Vasudevan K.   +8 more
europepmc   +1 more source

Characterization of a Fungal Modular Polyketide Synthase System Reveals an Unusual Strategy for Polyketide Chain Initiation

Angewandte Chemie, EarlyView.
Fungal modular polyketide synthases (PKSs) remain largely unexplored. Functional characterization of the LasC/LasD assembly line established its role in strasseriolide C biosynthesis and suggested an unexpected strategy for chain initiation, in which a malonyl unit is transferred from the module 2 acyl carrier protein (ACP) domains to the loading ACP ...
Qiaolin Ji, Chao Peng, Shuhan He, Bin‐Tao Peng, Wei‐Guang Wang, Yudai Matsuda   +5 more
wiley   +1 more source

A biased allosteric modulator is a molecular glue for β₂AR dimerization. [PDF]

Nature
Shen J, Peddada TN, Komolov KE, De Pascali F, Garces AM, Wang H, Ehsan M, Chae PS, Lerch MT, Benovic JL, Xu J, Kobilka BK.   +11 more
europepmc   +1 more source

Macrotranscriptomics analysis for decoding the role of <i>Klebsiella</i> variicola H8 in aroma compound biosynthesis during fermentation of reconstituted tobacco leaf concentrate. [PDF]

Front Bioeng Biotechnol
Feng Y, Qi W, Yang J, Liu W, Yang Z, Wang K, Mao D, Huang S, Zhang T.   +8 more
europepmc   +1 more source

Affinal parenthood after divorce: a socio-legal study of stepparent visitation rights in Peruvian blended families. [PDF]

Front Sociol
Castilla-Cabezudo JL, Zegarra-Castañeda R, Zegarra-Castañeda G, Díaz-Arias CC, Salcedo-Tenemas CJM.   +4 more
europepmc   +1 more source

Dynamic development of psychological resources among parents and primary caregivers in the context of home-kindergarten co-education: bidirectional associations and mediating pathways in a Chinese sample. [PDF]

Front Psychol
Gong S.
europepmc   +1 more source