Results 181 to 190 of about 22,424 (258)

Determinants of equivalent pathways and substitution effects on adolescents' physical activity within family contexts: a configurational analysis based on FsQCA method. [PDF]

BMC Public Health
Zhou X, Zhang X, Yang Z, Ma Y, Chen Y, Li K.   +5 more
europepmc   +1 more source

Unveiling the Complete Biosynthetic Pathway of Azacitidine: A Rare 1,3,5‐Triazine Nucleoside Derived From GTP

Angewandte Chemie, EarlyView.
The azacitidine biosynthetic gene cluster (aza BGC) was identified by the resistance‐gene‐guided comparative genomics method in Streptomyces mobaraensis IPIO2. The complete biosynthetic pathway of azacitidine, which follows a “base‐first‐then‐glycosylation” logic, was elucidated through in vivo and in vitro experiments.
Dan Wang, Qingxu Meng, Lingqi Hua, Mengjun Sun, Qianjin Kang, Min‐Juan Xu, Linquan Bai   +6 more
wiley   +1 more source

Enhancing monoclonal antibody diversity by integrating bulk sorting and machine learning. [PDF]

Biochem Biophys Rep
Hisamatsu D, Ozaki R, Ikeda A, Ito L, Matsushita Y, Hiki M, Mori H, Tabe Y, Naito T, Akazawa C.   +9 more
europepmc   +1 more source

Noncanonical Peloruside A Biosynthesis by an Uncultivated Verrucomicrobiota Symbiont

Angewandte Chemie, EarlyView.
Noncanonical biochemistry of the peloruside PKS characterized in this work, comprising double bond generation by a noncanonical tridomain (blue), acetyl‐CoA recycling (orange), and proofreading systems (purple and yellow). The Z‐double bond is installed by TEB1 through O‐acetylation and acetate elimination. The acyl ligase PelB (AL, orange) selectively
Amy E. Fraley, Michael Rust, Moritz Wagner, Ida R. Hipfinger, Paul J. N. Böhm, Cora L. Dieterich, Christopher M. Field, Michael J. Page, Jeremy G. Owen, Robert A. Keyzers, Shinichi Sunagawa, Jörn Piel   +11 more
wiley   +1 more source

REAP1/AtSWAP70 integrates RAB5 and ROP signalling during sexual reproduction. [PDF]

Nat Plants
Ito E, Rzepecka NJ, Ito Y, Hirano T, Ebine K, Oda Y, Sato MH, Nakano A, Uemura T, Ueda T.   +9 more
europepmc   +1 more source

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +1 more source

A critical role for STAT3 Thr714 phosphorylation in NPM-ALK-driven tumorigenesis. [PDF]

Sci Rep
Lin X, Yao Y, Moriwaki Y, Tago K, Funakoshi-Tago M.   +4 more
europepmc   +1 more source

Structure and Biosynthesis of Mangotoxin Produced by the Plant Pathogen Pseudomonas syringae

Angewandte Chemie, EarlyView.
The structure of mangotoxin remained elusive for over two decades. Here, mangotoxin was isolated from the native producer, Pseudomonas syringae pv. syringae, and was determined to be an alkyne‐containing dipeptide. Mangotoxin inhibited the growth of multidrug‐resistant human pathogen Klebsiella pneumoniae.
Alexis H. Murray, Sohan Hazra, Ryan W. Mull, Erinn M. O'Neill, Bo Li   +4 more
wiley   +1 more source

Discovery and development of a bispecific antibody for the treatment of hemophilia. [PDF]

Proc Natl Acad Sci U S A
Pao W.
europepmc   +1 more source

Supramolecular Cadmium‐Telluride Proteoliposomal Assemblies for Real‐Time Detection of Protein‐Catalyzed Pt(II)‐Complexes Transmembrane Translocation: Cu(I)‐Pumps Are Electrogenic Pt(II)‐Drug Uniporters

Angewandte Chemie, EarlyView.
Supramolecular mercaptosuccinic acid‐capped CdTe core‐type quantum dot‐encapsulated proteoliposome assemblies (MSA‐CdTe QD PLs) have been developed to study and unambiguously demonstrate real‐time transporter‐mediated turnover translocation of Pt(II)‐based complexes by transmembrane Cu(I) P‐type ATPase pumps (CopA).
Madujika A. Horadigala Gamage, Alessandra Barbanente, Nadeesha T. Liyana Withanage, Yalini H. Wijesundara, Jeremiah J. Gassensmith, Fabio Arnesano, Giovanni Natile, Gabriele Meloni   +7 more
wiley   +1 more source