Results 51 to 60 of about 4,220,681 (327)

A Novel Case of Tenosynovial Giant Cell Tumor at 4 Years After Total Knee Arthroplasty for Medial Osteoarthritis With Synovial Osteochondromatosis

Case Reports in Orthopedics
We report an unusual case of a tenosynovial giant cell tumor (TGCT) in a patient who received a total knee arthroplasty (TKA) for medial knee osteoarthritis with synovial osteochondromatosis (SO).
Yu-uichi Mishima, Takao Kaneko, Kosuke Shiga, Ayakane Yamamoto, Shu Yoshizawa   +4 more
doaj   +1 more source

CCT4 promotes tunneling nanotube formation

FEBS Letters, EarlyView.
Tunneling nanotubes (TNTs) are membranous tunnel‐like structures that transport molecules and organelles between cells. They vary in thickness, and thick nanotubes often contain microtubules in addition to actin fibers. We found that cells expressing monomeric CCT4 generate many thick TNTs with tubulin.
Miyu Enomoto, Akiko Asada, Taro Saito, Kanae Ando   +3 more
wiley   +1 more source

Early-stage reconstruction of flexor pollicis longus using palmaris longus in a patient with compartment syndrome of forearm: a case report

Journal of Medical Case Reports, 2022
Background The flexor pollicis longus is the most vulnerable muscle in acute compartment syndrome of the forearm. Reconstruction of a dysfunctional flexor pollicis longus is occasionally necessary following compartment syndrome of the forearm.
Muneyoshi Fujita, Hideaki Miyamoto, Taketo Kurozumi   +2 more
doaj   +1 more source

Agroforestry for a Changing Climate [PDF]

, 2019
The brief tackles the role of agroforestry in achieving food and nutritional security, climate change mitigation and environmental resilience. The publication is based on the small agroforestry project in Guinayangan Climate-Smart Village in Quezon ...
International Institute of Rural Reconstruction
core  

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

The Importance of Length of the Cephalomedullary Nails for Fixation of the Proximal Femoral Fractures: An Educational Corner

Journal of Orthopedic and Spine Trauma, 2021
No abstract is available.
Moein Khoori, Alireza Moharrami, Nima Hoseini Zare, SM Javad Mortazavi   +3 more
doaj   +1 more source

Building Community-Based Models for Climate Resilient Agriculture and Fisheries Across Landscapes within the Municipality of Ivisan, Capiz [PDF]

, 2017
A recent Inter-governmental Panel on Climate Change (IPCC) report states that climate change is unequivocal and its immediate impact is the modification of the worlds’ biophysical and natural systems resulting to changes in interspecies dynamics ...
International Institute of Rural Reconstruction
core   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source