Results 61 to 70 of about 1,312,102 (312)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Heart rate cost as a tool for monitoring recovery between acute training sessions

Purpose Effective recovery monitoring is crucial to optimise performance and prevent overreaching, injuries, and overtraining. This study evaluated the heart rate cost (HRC) during submaximal running as a simple, non-invasive, and costeffective tool to ...
Thiago dos Santos Rosa, Herbert Gustavo Simões, José Morais Souto Filho, Ricardo Yukio Assano, Andréa Cândida Arruda Andrade Rezende, Marcelo Magalhães Sales, Milton Rocha de Moraes, Fabiana Andrade Machado, Sergio Rodrigues Moreira, Larissa Alves Maciel, Patrício Lopes de Araújo Leite   +10 more
core   +1 more source

Estimating Default and Recovery Rate Correlations [PDF]

SSRN Electronic Journal, 2013
The paper analyzes a two-factor credit risk model allowing to capture default and recovery rate variation, their mutual correlation, and dependence on various explanatory variables. At the same time, it allows computing analytically the unexpected credit loss.
openaire   +3 more sources

Recovery rates, default probabilities, and the credit cycle [PDF]

Journal of Banking & Finance, 2010
In recessions, the number of defaulting firms rises. On top of this, the average amount recovered on the bonds of defaulting firms tends to decrease. This paper proposes an econometric model in which this joint time-variation in default rates and recovery rate distributions is driven by an unobserved Markov chain, which we interpret as the “credit ...
Max Bruche, Carlos González Aguado
openaire   +5 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Bank loans recovery rate in commercial banks:A case study of non-financial corporations [PDF]

Zbornik radova Ekonomskog fakulteta u Rijeci : časopis za ekonomsku teoriju i praksu, 2019
The empirical literature on credit risk is mainly based on modelling the probability of default, omitting the modelling of the loss given default. This paper is aimed to predict recovery rates on the rarely applied nonparametric method of Bayesian Model ...
Natalia Nehrebecka
doaj   +1 more source

Heart Rate Recovery Index In Patients With Psoriasis [PDF]

Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology, 2012
In clinical practice, autonomic functions are indirectly investigated with heart rate recovery (HRR) index measurements. Our aim was to evaluate the HRR index in patients with psoriasis, which is a systemic inflammatory disease.The study population included 39 psoriasis patients (18 female, mean age 48±15 years) and 40 control group (18 female, mean ...
Serkan, Bulur, Hakan, Turan, Yusuf, Aslantaş, Zehra, Gürlevik, Mustafa, Ozşahin, Handan, Ankaralı, Ismail, Ekinözü, Sabri Onur, Cağlar, Hakan, Ozhan   +8 more
openaire   +3 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Process Optimization of a Gold Smelter in Shandong Province

Kuangchan zonghe liyong
By optimizing the grinding process and reagent system of flotation operation before cyanidation leaching, the overgrinding of gold concentrate is avoided, and the efficient comprehensive recovery of associated minerals is realized, which increases the ...
Guanglin QIN
doaj   +1 more source

RECOVERY RATE AND QUALITY OF EMBRYOS AS AFFECTED BY REPEATED SURGICAL COLLECTION FROM NEW ZEALAND WHITE AND BALADI RABBIT DOES. [PDF]

Journal of Animal and Poultry Production, 2010
Total of 12 New Zealand white (NZW, n=6) and Baladi black (BB, n=6) rabbit does (6-7 mo of age and 3.25-3.50 kg LBW) as embryo donors and two fertile bucks one from each breed (7.5-8 mo of age and 3.5-4 kg LBW) for natural mating during the experimental ...
Rania Ali, Sh. Shamiah, A. Abdel-Khalek
doaj   +1 more source