Results 71 to 80 of about 7,578,607 (249)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Process Optimization of a Gold Smelter in Shandong Province

Kuangchan zonghe liyong
By optimizing the grinding process and reagent system of flotation operation before cyanidation leaching, the overgrinding of gold concentrate is avoided, and the efficient comprehensive recovery of associated minerals is realized, which increases the ...
Guanglin QIN
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

EFFECT OF SPIRULINA SUPPLEMENTATION IN DIARRHEIC BUFFALO CALVES [PDF]

Assiut Veterinary Medical Journal
This study was conducted to investigate the effects of Spirulina platensis supplementation on hematological, biochemical, and immunological parameters in healthy and diarrheic buffalo calves, as well as the role of Spirulina supplementation in improving ...
DOAA WAHEED, MOHAMED EL-DIASTY, SHIMAA ZAYED, ELSAYED GABR   +3 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Numerical simulation of underground hydrogen storage performance in aquifers

You-qi chuyun
Objective With the global energy transition, the technology of underground hydrogen storage in aquifers has become a key area of research due to its significant potential for large-scale energy storage.
Weimin HONG, Xinran YU, Yuxing LI
doaj   +1 more source

Effect of Ga Addition on Morphology and Recovery of Primary Si During Al–Si Alloy Solidification Refining

High Temperature Materials and Processes, 2015
The effect of Ga addition on alloy macrostructure, morphology and recovery rate of primary Si during the Al–Si–Ga alloy solvent refining process of silicon was studied in this work.
Li Jingwei, Bai Xiaolong, Li Yanlei, Ban Boyuan, Chen Jian   +4 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Depth-responsive mechanisms of carbon sequestration-enhanced gas recovery mechanisms and critical burial depth effects

Meitan xuebao
CO2/N2 mixed gas injection into deep, non-recoverable coal seams is an efficient method for carbon sequestration and recovery enhancement (GM-ECBM). Based on an improved thermos-hydro-mechanical (THM) coupling model for multicomponent gas injection and a
Zhanglei FAN, Gangwei FAN, Dongsheng ZHANG, Xuesen HAN, Chuangnan REN, Xin YUE, Yibo FAN, Congxin YANG, Shizhong ZHANG   +8 more
doaj   +1 more source