Results 61 to 70 of about 2,925,455 (290)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

The “Hand as Foot” teaching method for the utilization of straight and curved laryngoscope in anesthesia-nurse training

Asian Journal of Surgery, 2023
Tianqin Gao, Linlin Huang, Xuemeng Teng, Xiuzhen Liu   +3 more
doaj   +1 more source

Surrounding rock deformation and stress evolution in pre-driven longwall recovery rooms at the end of mining stage

International Journal of Coal Science & Technology, 2019
Two case studies were conducted in the Shennan mining area of Shaanxi Province, China to evaluate the surrounding rock deformation and stress evolution in pre-driven longwall recovery rooms. These studies mainly monitored the surrounding rock deformation
Bonan Wang, Faning Dang, Wei Chao, Yanping Miao, Jun Li, Fei Chen   +5 more
doaj   +1 more source

Effect of Bypass Control and Room Control Modes on Fan Energy Savings in a Heat Recovery Ventilation System

Energies, 2020
This study makes a novel attempt to analyse the effect of the bypass control and room control modes on ventilation energy saving in an 84 m2 housing unit, which is the most frequently constructed unit-type among newly constructed apartment buildings in ...
Kyungjoo Cho, Dongwoo Cho, Taeyeon Kim
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

An Investigation on the Current Status of the Operation Recovery Rooms in Yazd Hospitals in 2010-2011

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2012
Introduction: The recovery ward is a vital unit to care patients awaking from anesthesia and is a standard requirement for the operating room. Recovery ward is located adjacent to the operation room and is easily accessible to trained and skilled ...
MR Khajeh Aminian, A Entezari, MH Abdollahi, MH Zare   +3 more
doaj  

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Specifying the Objectives and Techniques of a Competency-based Training Program to Improve Post-anesthesia Care Unit Nurse Performance: A Delphi Study

Iranian Journal of Nursing and Midwifery Research
Background: Clinical competence in detecting complications is crucial for anesthesia nurses working in the Post-Anesthesia Care Unit (PACU). This study utilized the Delphi method to identify essential core competency-based learning objectives for this ...
Ali Khalafi, Masoumeh Behzadi, Nooshin Sarvi-Sarmeydani, Vahid Saidkhani   +3 more
doaj   +1 more source