Results 71 to 80 of about 2,925,455 (290)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Quarterly report of Connecticut Resources Recovery Authority operations for the quarter ending ...; Quarterly report of CRRA operations for the quarter ending ...

, 2009
Quarterly; Began with Mar. 31, 2004?; Description based on: Mar. 31, 2004; title from foot of p. 1 (publisher's web site, viewed Nov. 19, 2008).; Latest issue consulted: June 30, 2008 (viewed Nov.
Connecticut Resources Recovery Authority.
core   +4 more sources

Comments on "Low-Dose Morphine Intrathecal Analgesia in Elderly Patients with Hip Fracture Undergoing Single Spinal Anesthesia: A Randomized Controlled Trial” [Letter]

Local and Regional Anesthesia
Wenjuan Qiao, Jie MengDepartment of Anesthesiology, The Second Affiliated Hospital of Dalian Medical University, Dalian, People’s Republic of ChinaCorrespondence: Jie Meng, Department of Anesthesiology, The Second Affiliated Hospital of Dalian ...
Qiao W, Meng J
doaj  

Education and Treatment Guideline for Evaluation of Applying Basic Standards of Anesthesia Care in Surgery [PDF]

مجله ایرانی آموزش در علوم پزشکی, 2011
Introduction: Applying basic standards of anesthesia care is crucial. Patients’ status should be evaluated based on a standard checklist. In case of mismanagement, logical approaches must be conducted.
Mohammadreza safavi, Hossein Mahjobipor, Mohammadali Mohammadzadeh, Azim Honarmand   +3 more
doaj  

Recovery From Alcohol and Other Drug Problems in the U.S. Population: Prevalence, Pathways, and Predictors [PDF]

, 2018
The concept of "recovery" has become the organizing paradigm in many middle and high income countries globally with a goal of orienting services in cost effective ways to help sufferers achieve and maintain long term remission. Despite this focus, little
Hoeppner, Bettina, Hoffman, Lauren, Eddie, David, Bergman, Brandon, Kelly, John, Vilsaint, Corrie   +5 more
core   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Community Colleges: The Next Frontier of Recovery Support at Institutions of Higher Education [PDF]

, 2018
In 2016, TYR could identify only six community colleges offering recovery support programs and services. Based on this finding, TYR identified a need for pilot programs to better understand programmatic models that may be effective for supporting ...
Jones, Erin K
core   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Methodological Considerations on the Optimal Duration of Dual Antiplatelet Therapy in Patients with High Residual Inflammatory Risk [Letter]

Journal of Inflammation Research
Tianrui Yang, Jie Meng, Xiaoyu WangDepartment of Anesthesiology, The Second Affiliated Hospital of Dalian Medical University, Dalian, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaoyu Wang ...
Yang T, Meng J, Wang X
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