Results 221 to 230 of about 290,718 (305)

The staff perspectives of facilitators and barriers to implementing virtual reality for people living with dementia in long-term care. [PDF]

Front Dement
Wong J, Wong KLY, Kan W, Wu C, Upreti M, Van M, Temirova A, Alfares H, Wen K, Sharma V, Wallsworth C, Mann J, Wong L, Hung L.   +13 more
europepmc   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Outdoor play in Europe: terminology and state of research, practice, and policy. [PDF]

Eur J Public Health
Mygind L, Johnstone A, Kryeziu AR, Billet B, Nyström CD, Sandseter EB, Mäestu E, Lemberg GM, Cante G, Dodd H, Brazo-Sayavera J, Jarani J, Maciaszek K, Rentzou K, Bølling M, Bloemen MAT, Mannello M, Bradwell M, Löf M, Kangas M, Leather M, Bergin M, Bezjak N, Bakalár P, Salaj S, Morrison SA, Siklander S, Veiga-Seijo S, Popovic S, Csányi T, Morgenthaler T, Bentsen P.   +31 more
europepmc   +1 more source

The preparation of physical education majors in adventure activities [PDF]

, 1992
Gass, Michael A., Uhlendorf, Karen J.
core   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Investigating pathways to environmental civic engagement for diverse communities. [PDF]

Environ Manage
Hamaneh AB, Dayer AA, Drape TA, Chaves WA.   +3 more
europepmc   +1 more source

Size‐Modulated Mesoderm‐Endoderm Divergence and Myocardial Cavitation in Micropatterned Cardioids

Advanced Science, EarlyView.
Micropatterned cardioids, CRISPR‐engineered reporter hiPSCs, deep‐tissue imaging, and single‐cell RNA sequencing are integrated to model mesoderm‐endoderm co‐development. Heart‐foregut crosstalk promotes single large cavitation inside cardioids, resembling early heart chamber formation. ABSTRACT The human heart, originating from the splanchnic mesoderm,
Plansky Hoang, David W. McKellar, Andrew Kowalczewski, Nhu Y. Mai, Meng Chai, Xiaojun L. Lian, Yi Zheng, Jeffrey Amack, Nathan Tucker, Iwijn De Vlaminck, Huaxiao Yang, Benjamin D. Cosgrove, Zhen Ma   +12 more
wiley   +1 more source

Taking a partnership approach to embed physical activity in local policy and practice: a Bradford District case study. [PDF]

Int J Behav Nutr Phys Act
Hall J, Lever E, Dawkins N, Young E, Crowther J, Williams R, Pickavance J, Barber S, Daly-Smith A, Chalkley A, wider JU:MP team.   +10 more
europepmc   +1 more source

Mechanostimulatory Cues Determine Intestinal Fibroblast Fate and Profibrotic Remodeling in a Physiodynamic Human Gut‐on‐a‐Chip

Advanced Science, EarlyView.
A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min, Nam Than, Yong Cheol Shin, Elif G. Ertugral, Chandrasekhar R. Kothapalli, Olumuyiwa Awoniyi, Hyun Jung Kim   +6 more
wiley   +1 more source