Results 191 to 200 of about 549,989 (310)

Interannual wave-driven shoreline change on the California coast. [PDF]

Nat Commun
O'Reilly WC, Merrifield MA, Cagigal L, Yoon D, Leslie-Bole H, Adusumilli S, Young AP, Vos K, Guza RT.   +8 more
europepmc   +1 more source

Ovarian Matrisome Dynamics and αvβ3‐Mediated Regulation in Early Follicular Development

Advanced Science, EarlyView.
The matrisome undergoes dynamic remodeling during early follicular development. Integrin αvβ3 mediates matrisome signals, regulating primordial follicle activation/atresia and secondary follicle growth via Hippo/mTOR pathways, with conserved roles in human ovaries, offering therapeutic targets for ovarian disorders.
Tong Wu, Yanzhi Feng, Qingqing Zhu, Ting Jiang, Yueyue Gao, Kebing Nie, Xianan Tang, Ying Chen, Dianxing Hu, Xudan Yang, Shixuan Wang, Meng Wu, Jinjin Zhang   +12 more
wiley   +1 more source

Temporal displacement of the mammal community in a protected area due to hunting and recreational activities. [PDF]

Ecol Appl
Peters A, Smith AF, Henrich M, Dormann CF, Heurich M.   +4 more
europepmc   +1 more source

QBP1 Peptide as a Potential Anti‐Amyloidogenic Therapy for Type 2 Diabetes: An In Vitro Study

Advanced Science, EarlyView.
The anti‐amyloidogenic peptide QBP1 effectively halts human islet amyloid polypeptide (hIAPP) aggregation, preventing the formation of toxic β‐structured intermediates. Through a combination of biophysical assays, molecular dynamics, and cell‐based studies, QBP1 is shown to preserve β‐cell viability and metabolic homeostasis, positioning it as a ...
María M. Tejero‐Ojeda, Ada Bernaus Vives, Michał Wojciechowski, Dinh Quoc Huy Pham, Mateusz Chwastyk, Mario Vallejo, Anna Novials, Douglas V. Laurents, Mariano Carrión‐Vázquez   +8 more
wiley   +1 more source

The mediating role of recreational flow experience in the relationship between adventure behavior seeking and event satisfaction among participants in outdoor leisure activities. [PDF]

BMC Psychol
Erciş S, Budak D.
europepmc   +1 more source

RETREG1‐Mediated Reticulophagy is Essential for Dendritic Cell Maturation and Function in Sepsis

Advanced Science, EarlyView.
Reticulophagy regulator 1 (RETREG1) maintains dendritic cell (DC) maturation and function in early sepsis. Mechanistically, activating transcription factor 6 (ATF6) acts as a direct transcription factor regulating RETREG1 expression in response to sepsis‐induced endoplasmic reticulum (ER) stress.
Ren‐Qi Yao, Chao Ren, Li‐Yu Zheng, Jing‐Yan Li, Wen‐Feng Wu, Yu‐Xuan Li, Li‐Xue Wang, Yu Duan, Lu Wang, Shuang‐Qing Liu, Peng‐Yi He, Peng‐Yue Zhao, Sen Tong, Zhi‐Xuan Li, Tuo Zhang, Meng‐Yao Wu, Shu‐Ting Wei, Ning Dong, Yao Wu, Hui Zhang, Xiao‐Mei Zhu, Zi‐Cheng Zhang, Guo‐Sheng Wu, Zhao‐Fan Xia, Xiao‐Hui Du, Hong‐Jun Kang, Zui Zou, Dao‐Lin Tang, Yong‐Ming Yao   +28 more
wiley   +1 more source

Towards equitable and immersive outdoor orienteering: An artificial intelligence-driven multi-objective route planning framework with augmented sand cat swarm optimization. [PDF]

PLoS One
Lun Q, Li B, Zhou Y.
europepmc   +1 more source

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

High tibial osteotomy with individualised alignment and meniscal centralisation improves KOOS sports and recreation and cartilage status compared to conventional Fujisawa-point alignment without centralisation: A propensity score matching study. [PDF]

J Exp Orthop
Horita K, Ikeda Y, Kamiya T, Hamaoka K, Takahashi K, Okada Y, Emori M, Teramoto A.   +7 more
europepmc   +1 more source

Evaluation Of Recreation Possibilities According to User Requests Of Mudanya District Coastal Line in Bursa Province

Coasts have been one of the most important recreational areas from past to present. The coastal areas where people have many recreational activities based on water are the most important areas that establish a relationship between sea-human-nature.
Akdeniz, Nilüfer Seyidoğlu, Batman, Zeynep Pirselimoğlu, Çelik, Aysun, Ender, Elvan   +3 more
openaire   +1 more source