Results 211 to 220 of about 549,989 (310)

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Correlation between Kellgren-Lawrence classification of osteoarthritis and Knee Injury and Osteoarthritis Outcome Score. [PDF]

World J Orthop
Alshahrani AS, Aljaffar AB, Albin Ahmed BJ, Altabash MW, Dajani ZA, Alamer AH, Alzawad AJ, Alanii F, Alzahrani MM.   +8 more
europepmc   +1 more source

Size‐Modulated Mesoderm‐Endoderm Divergence and Myocardial Cavitation in Micropatterned Cardioids

Advanced Science, EarlyView.
Micropatterned cardioids, CRISPR‐engineered reporter hiPSCs, deep‐tissue imaging, and single‐cell RNA sequencing are integrated to model mesoderm‐endoderm co‐development. Heart‐foregut crosstalk promotes single large cavitation inside cardioids, resembling early heart chamber formation. ABSTRACT The human heart, originating from the splanchnic mesoderm,
Plansky Hoang, David W. McKellar, Andrew Kowalczewski, Nhu Y. Mai, Meng Chai, Xiaojun L. Lian, Yi Zheng, Jeffrey Amack, Nathan Tucker, Iwijn De Vlaminck, Huaxiao Yang, Benjamin D. Cosgrove, Zhen Ma   +12 more
wiley   +1 more source

Fishing-focused marine conservation planning underestimates losses of other ecosystem benefits to local communities. [PDF]

Sci Rep
Hamel MA, Pressey RL, Andréfouët S, Hicks C.   +3 more
europepmc   +1 more source

Mechanostimulatory Cues Determine Intestinal Fibroblast Fate and Profibrotic Remodeling in a Physiodynamic Human Gut‐on‐a‐Chip

Advanced Science, EarlyView.
A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min, Nam Than, Yong Cheol Shin, Elif G. Ertugral, Chandrasekhar R. Kothapalli, Olumuyiwa Awoniyi, Hyun Jung Kim   +6 more
wiley   +1 more source

Improved Coronal Alignment Using the Preemptive Joint Line Convergence Angle Compensation Method in Medial Open Wedge High Tibial Osteotomy: A Retrospective Propensity Score-Matched Analysis. [PDF]

Orthop J Sports Med
Byun J, Jung M, Chung K, Moon HS, Jung SH, Kang KT, Kim SH.   +6 more
europepmc   +1 more source

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, EarlyView.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

Immediate health and wellbeing benefits of short-term forest therapy for urban healthcare workers: a case study in Giant Panda National Park with cultural ecosystem services. [PDF]

Front Psychol
Zhang P, Cui Y, Liu R, Zhao Y, Su W, Zhao L, Wang X, Deng L, Wang B, Li J, Yang Y, Chen M, Guo W, Song L, Zhang Q, Xie F, Cao S, Wang G, Zhang T, Yang S, Li X.   +20 more
europepmc   +1 more source

Structural Eigenmodes of the Brain to Improve the Source Localization of EEG: Application to Epileptiform Activity

Advanced Science, EarlyView.
Geometry and connectivity are complementary structures, which have demonstrated their ability to represent the brain's functional activity. This study evaluates geometric and connectome eigenmodes as biologically informed constraints for EEG source localization.
Pok Him Siu, Philippa J. Karoly, Sina Mansour L., Artemio Soto‐Breceda, Levin Kuhlmann, Mark J. Cook, David B. Grayden   +6 more
wiley   +1 more source

Environmental Yeast Abundance and Diversity Assessment in Recreation Areas of Bangkok, Thailand. [PDF]

Environ Microbiol Rep
Singkum P, Wongsuk T, Pumeesat P, Cheewapat R, Ebersberger I, Thummeepak R, Aroonnual A.   +6 more
europepmc   +1 more source