Results 161 to 170 of about 1,287,280 (249)

Running a clinical trial remotely: Lessons learnt from a decentralised multicentre randomised controlled trial evaluating a digital health intervention for Chronic Kidney Disease. [PDF]

PLOS Digit Health
Sohansoha GK, Vadaszy N, Ford EC, Wilkinson TJ, Graham-Brown M, Smith AC, Lightfoot CJ.   +6 more
europepmc   +1 more source

Clinical Spectrum and Outcomes of SOX1 Antibody‐Associated Paraneoplastic Neurological Syndromes: A Chinese Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background SOX1 antibody‐positive paraneoplastic neurological syndromes (PNS) exhibit significant population‐specific clinical heterogeneity. While Western cohorts predominantly manifest Lambert‐Eaton myasthenic syndrome (65%–80%), comprehensive clinical characterization and treatment response data in Asian populations remain critically ...
Jin‐Long Ye, Zu‐Ying Kuang, Bo Li, Meng‐Qiu Pan, Li‐Hua Zhou, Yang‐Yang Dai, Si‐Fen Xie, Xian‐Guang Lin, Ye‐Peng Hu, Li‐Hong Jiang, Zhan‐Hang Wang, Wei‐Jing Zhang   +11 more
wiley   +1 more source

Randomized controlled trial on feedback-informed internet-delivered psychodynamic therapy for adolescents with depression: A trial that failed to recruit enough participants. [PDF]

Internet Interv
Philips B, Mechler J, Uckelstam CJ, Andersson G, Carlbring P, Edbrook-Childs J, Falkenström F, Johansson R, Lilliengren P, Bergsten KL, Midgley N, Sandell R, Thorén A, Topooco N, Ulberg R, Lindqvist K.   +15 more
europepmc   +1 more source

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source

Who needs closure? Estimating abundance with a Markovian availability model for geographically open removal sampling. [PDF]

Ecology
Perry RW, Pope AC, Hendrix AN, Kirsch JE, Matthias BG, Dodrill MJ.   +5 more
europepmc   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

A brief digital screening tool to address parental and adolescent tobacco and electronic cigarette use in paediatric medical care in Canada: a pilot randomized controlled trial. [PDF]

Pilot Feasibility Stud
Drouin O, Perez T, Diamant É, Namuhoranye C, Mitri S, Al-Saleh A, Sylvestre MP, O 'Loughlin J, Winickoff JP, Chadi N.   +9 more
europepmc   +1 more source

Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel, Timothy P. Siejka, Cassandra Marotta, Josh J. Y. Lee, Kelly Bertram, Terence J. O'Brien, Meng Law, Lucy Vivash, Ian H. Harding   +8 more
wiley   +1 more source

Sociodemographic Drivers of Recruitment and Attrition in Digital Neurological Research: Longitudinal Cohort Study.

J Med Internet Res
Nejat P, Bachman AD, Stubbs VM, Duffy JR, Stricker JL, Herasevich V, Jones DT, Utianski RL, Botha H.   +8 more
europepmc   +1 more source

Physiological foundation modeling for subclinical disease assessment: a prospective pilot. [PDF]

JAMIA Open
Yuan W, Xu S, Dionisi S, von Herrmann K, Frederick-Dyer K, Cheung-Flynn J, Kennedy C, Flynn CR, Lipnick S.   +8 more
europepmc   +1 more source