Results 41 to 50 of about 1,287,280 (249)

Facilitating Development Research: Suggestions for Recruiting and Re-Recruiting Children and Families

Frontiers in Psychology, 2017
Recruiting children and families for research studies can be challenging, and re-recruiting former participants for longitudinal research can be even more difficult, especially when a study was not prospectively designed to encompass continuous data ...
Lisa B. Hurwitz, Kelly L. Schmitt, Kelly L. Schmitt, Megan K. Olsen   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Effect of mindfulness group therapy on maternal psychological distress and perinatal outcomes in twin pregnancy: a randomized controlled trial

Frontiers in Psychiatry
PurposePsychosocial stress, depression, and anxiety are prevalent during pregnancy and can be associated with adverse birth outcomes. This study aimed to evaluate the effectiveness of an online Mindfulness Group Therapy (MGT) program in improving ...
Ying Zhou, Zai-Mei Tang, Lin Mei, Xiao-Chang Yang, Hong-Ling Zheng, Bi-Zhen Liao, Xin-Yang Yu   +6 more
doaj   +1 more source

Components of population growth for Arctic foxes at a large Arctic goose colony: the relative contributions of adult survival and recruitment

Polar Research, 2017
The abundance and distribution of animals often vary dramatically among years in Arctic environments. Such variation, in turn, is closely related to changes in food abundance and its effect on vital rates such as survival and recruitment.
Gustaf Samelius, Ray T. Alisauskas
doaj   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Tunneling nanotube-mediated stem cell immunomodulation dysfunction promotes adipose inflammation and insulin resistance in GDM

Cell Reports
Summary: Adipose-derived stem cells (ADSCs) represent a promising therapeutic resource, yet their immunometabolic regulation remains poorly defined. Here, we reveal a tunneling nanotube (TNT)-mediated communication mechanism between ADSCs and adipose ...
Bingnan Chen, Xuyang Chen, Jianxin Li, Ruohan Hu, Lijun Yang, Hongli Li, Xinmi Liu, Richard D. Cannon, Richard Saffery, Boris Novakovic, Hongbo Qi, Hua Zhang, Xiaobo Zhou   +12 more
doaj   +1 more source

Drosophila DNA-Binding Proteins in Polycomb Repression

Epigenomes, 2018
The formation of individual gene expression patterns in different cell types is required during differentiation and development of multicellular organisms.
Maksim Erokhin, Pavel Georgiev, Darya Chetverina   +2 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Multi-step coordination of telomerase recruitment in fission yeast through two coupled telomere-telomerase interfaces

eLife, 2016
Tightly controlled recruitment of telomerase, a low-abundance enzyme, to telomeres is essential for regulated telomere synthesis. Recent studies in human cells revealed that a patch of amino acids in the shelterin component TPP1, called the TEL-patch, is
Xichan Hu, Jinqiang Liu, Hyun-IK Jun, Jin-Kwang Kim, Feng Qiao   +4 more
doaj   +1 more source