Results 91 to 100 of about 449,004 (237)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Li Maneuver for Geotropic Right HC-BPPV, Canalithiasis

, 2023
The Li maneuver is used to treat horizontal canal, canalithiasis. When compared to the Gufoni maneuver, the Li maneuver was as effective to treat HC-BPPV and there was no significant difference between the maneuvers; however, the Li Maneuver may take ...
Allison Nogi, DPT
core  

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Pulmonary recruitment maneuver to reduce pain after laparoscopy: a meta-analysis of randomized controlled trials

, 2015
Background: We investigated the impact of pulmonary recruitment maneuver in reducing shoulder pain after laparoscopic procedure. Methods: We conducted a systematic review of the literature using Medline (1966–2014), Scopus (2004–2014), Popline (1974–2014)
Vlachos, G.D., Pergialiotis, V., Kontzoglou, K., Vlachos, D.-E.G., Perrea, D.   +4 more
core   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Slow moderate pressure recruitment maneuver minimizes negative circulatory and lung mechanic side effects: evaluation of recruitment maneuvers using electric impedance tomography

, 2005
OBJECTIVE: To evaluate the efficacy of different lung recruitment maneuvers using electric impedance tomography. DESIGN AND SETTING: Experimental study in animal model of acute lung injury in an animal research laboratory.
Odenstedt, Helena,, Lethvall, Sven,, Stenqvist, Ola,, Lundin, Stefan,, Lindgren, Sophie,, Erlandsson, Karin,, Olegård, Cecilia,, Åneman, Anders,   +7 more
core   +1 more source

Effect of pulmonary recruitment maneuver and intraperitoneal bupivacaine on post-operative shoulder pain after laparoscopic cholecystectomy: A randomized comparative study

Asian Journal of Medical Sciences
Background: Laparoscopic cholecystectomy nowadays is the preferable approach over open cholecystectomy because of early recovery and lower rate of complications. However, some undesirable effects, such as shoulder pain, which has an incidence of about 12–
Sedevino Nakhro , Reetu Verma , Hemlata , Aparna Shukla , Rajni Gupta   +4 more
doaj   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

The Gans Maneuver for Right Posterior Canal Benign Paroxysmal Positional Vertigo (Video)

, 2023
This maneuver is recommended for individuals with cervical restrictions or precautions, as the maneuver avoids cervical hyperextension and may reduce cervical pain associated with repositioning maneuvers.
Allison Nogi, DPT
core