Results 81 to 90 of about 449,004 (237)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A recruitment maneuver improves apneic oxygenation

, 2011
Background. Apneic oxygenation (AO) is applied during surgery and in intensive care units. Even with AO, apnea is associated with progressive hypoxemia, limiting the tolerable amount of time in AO.
Tanju, S., Ziyade, S., Şentürk, Erdem, Cakar, N., Ozcan, Perihan, Tugrul, S.   +5 more
core  

Effectiveness of Aggressive Intraoperative Pulmonary Recruitment Maneuver in Limiting Immediate Postoperative Pathological Atelectasis Immediately before Weaning from Cardiopulmonary Bypass [PDF]

Objective: To determine effectiveness of aggressive Intraoperative Pulmonary recruitment maneuver before weaning in limiting immediate postoperative pathological Atelectasis in patients with coronary artery bypass surgery Methodology: This retrospective ...
Rabbi, Jamal, Aurangzeb, Mahmud, Javed Iqbal, Wazir, Sangeen Khan, Saifullah, Iqbal Khan, Qadir, Mamoon   +5 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

The effects of 'recruitment' maneuver on laparoscopic colon surgery

, 2010
Objective: During general anesthesia and iatrogenic pneumoperitoneum practice, some factors resulting in formation of atelectasia such as increased intra-abdominal pressure, decreased functional residual capacity and lung compliance can affect the ...
Yeksan, Aysenur, Topuz, Ufuk, Karatas, Adem, SALİHOĞLU, ZİYA   +3 more
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Influence of tidal volume on alveolar recruitment. respective role of PEEP and a recruitment maneuver

, 2001
Both reduction in tidal volume (VT) and alveolar recruitment may be important to limit ventilator-associated lung injury during mechanical ventilation of patients with the acute respiratory distress syndrome (ARDS).
Mancebo, Jordi, Richard, Jean-Christophe, Maggiore, Salvatore M, Jonson, Björn, Maggiore, Salvatore Maurizio, Lemaire, Francois, Brochard, Laurent   +6 more
core  

Additional file 1 of Respiratory effects of lung recruitment maneuvers depend on the recruitment-to-inflation ratio in patients with COVID-19-related acute respiratory distress syndrome

, 2022
Additional file 1. Method E1: Esophageal pressure measurement; Method E2: Ventilatory ratio calculation; Table E1: Lung recruitment maneuver and titration of the optimal positive end-expiratory pressure; Table E2: Effects of lung recruitment maneuver ...
Loay Kontar (4913362), Alexis Lambour (11905519), Clément Brault (11905531), Thierry Soupison (11905525), Thomas Bradier (11905528), Bertrand De Cagny (11905522), Julien Maizel (546218), Michel Slama (4615414), Yoann Zerbib (8459880)   +8 more
core   +1 more source

Effect of different lung recruitment maneuvers on postoperative respiratory outcomes and lung aeration, assessed by lung ultrasound, in patients undergoing thoracoscopic sympathectomy: a randomized controlled trial

BMC Anesthesiology
Background Atelectasis is a primary cause of impaired oxygenation and reduced respiratory compliance during general anesthesia. Recruitment maneuvers (RMs) can effectively counteract atelectasis; however, the optimal protocol regarding pressure, timing ...
Dandan Chen, Yuqian Chen, Yanyu Wu, Xianzhong Lin   +3 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source