Results 121 to 130 of about 4,894,740 (406)

MR Imaging of Rectal Cancer: Radiomics Analysis to Assess Treatment Response after Neoadjuvant Therapy.

Radiology, 2018
Purpose To investigate the value of T2-weighted-based radiomics compared with qualitative assessment at T2-weighted imaging and diffusion-weighted (DW) imaging for diagnosis of clinical complete response in patients with rectal cancer after neoadjuvant ...
N. Horvat, H. Veeraraghavan, Monika Khan, Ivana Blažić, Junting Zheng, M. Capanu, E. Sala, J. García-Aguilar, M. Gollub, I. Petkovska   +9 more
semanticscholar   +1 more source

KLK1 as an Epithelial‐Specific Brake Inhibits Colorectal Tumorigenesis by Suppressing B1R‐Mediated Fibroblast Phenotypic Transition

Advanced Science, EarlyView.
KLK1 downregulation disrupts the intestinal mucosal barrier and impairs kallikrein‐kinin signaling, thereby reducing Lys‐des‐Arg9‐BK production. This enhances B1R activation on ADAMDEC1⁺ fibroblasts, promoting inflammation and extracellular matrix (ECM) remodeling. The resulting iCAFs promote colorectal cancer progression, highlighting a novel KLK1‐B1R
Lisha Zhou, Meijing Wang, Shunji Liu, Limei Gu, Shijia Liu, Qianming Du, Tianyi Zhang, Yinuo Ma, Lixin Zhao, Jiaming Wang, Qiang Xu, Tingsheng Ling, Haibo Cheng, Hongqi Chen, Yang Sun   +14 more
wiley   +1 more source

Multifractal characteristics of external anal sphincter based on sEMG signals

, 2017
This work presents the application of Multifractal Detrended Fluctuation Analysis for the surface electromyography signals obtained from the patients suffering from rectal cancer.
Machura, Lukasz, Nowakowski, Michal, Trybek, Paulina   +2 more
core   +1 more source

Reducing gastrointestinal anastomotic leak rates: Review of challenges and solutions [PDF]

, 2016
Various techniques and interventions have been developed in an effort to obviate gastrointestinal anastomotic leaks. This review is intended to delineate potential modifications that can be made to reduce the risk of anastomotic leaks following ...
Philllips, Benjamin
core   +4 more sources

A Population-Based Study of Secondary Prostate Cancer Risk after Radiotherapy in Male Patients with Rectal Cancer: A Retrospective Cohort Study

Medicina, 2019
Background and objective: Risk of secondary prostate cancer after radiation therapy among patients with rectal cancer remains undetermined. Given an increased incidence of rectal cancer in younger people and improved survival for rectal cancer patients ...
Jen-Pin Chuang, Yen-Chien Lee, Jenq-Chang Lee, Chin-Li Lu, Chung-Yi Li   +4 more
doaj   +1 more source

Safety and Feasibility of Using Magnetic Resonance Imaging Criteria to Identify Patients With "Good Prognosis" Rectal Cancer Eligible for Primary Surgery: The Phase 2 Nonrandomized QuickSilver Clinical Trial.

JAMA Oncology, 2019
Importance Chemoradiotherapy (CRT), followed by surgery, is the recommended approach for stage II and III rectal cancer. While CRT decreases the risk of local recurrence, it does not improve survival and leads to poorer functional outcomes than surgery ...
E. Kennedy, M. Šimunović, K. Jhaveri, R. Kirsch, J. Brierley, S. Drolet, C. Brown, P. Vos, W. Xiong, T. MacLean, S. Kanthan, P. Stotland, S. Raphael, Gil Chow, Catherine O’Brien, C. Cho, C. Streutker, R. Wong, S. Schmocker, S. Liberman, C. Reinhold, N. Kopek, V. Marcus, A. Bouchard, C. Lavoie, S. Morin, M. Périgny, A. Wright, Katerina Neumann, S. Clarke, N. Patil, T. Arnason, L. Williams, R. McLeod, G. Brown, A. Mathieson, A. Pooni, N. Baxter   +37 more
semanticscholar   +1 more source

Tumor Intrinsic METTL5 Modulates ATF4 Translation to Prevent T Cell‐Induced Ferroptosis in Ovarian Cancer

Advanced Science, EarlyView.
An integrative analysis combining in vitro genome‐wide immune screens, in vivo ICB screens, and clinical data mining identifies METTL5 as a key tumor‐intrinsic immune factor. Mechanistic studies further reveal the importance of the METTL5‐ATF4‐SLC7A11/SLC3A2‐ferroptosis axis in modulating antitumor immune responses. These findings highlight METTL5 as a
Jiakai Hou, Cheng‐Wei Ju, Nicholas A. Egan, Yanjun Wei, Yunfei Wang, Minghao Dang, Tianyi Zhou, Leilei Shi, Ningbo Zheng, Si Chen, Ashley M. Guerrero, Xiaofang Liang, Wanfu Wu, Areej Akhtar, Chitra Dhiman, Debanwita Roy Burman, Andro E. Gerges, Mason D. Flores, Han Li, Li‐Sheng Zhang, Marleen Kok, Xiaobo Mao, Linghua Wang, Qin Feng, Yiwen Chen, Sanghoon Lee, Daniel J. McGrail, Nidhi Sahni, Chuan He, Amir A. Jazaeri, Weiyi Peng   +30 more
wiley   +1 more source

Complete mesocolic excision does not increase short-term complications in laparoscopic left-sided colectomies : a comparative retrospective single-center study [PDF]

, 2019
Background: Since the implementation of total mesorectal excision (TME) in rectal cancer surgery, oncological outcomes improved dramatically. With the technique of complete mesocolic excision (CME) with central vascular ligation (CVL), the same surgical ...
Claeys, Donald, Defoort, Barbara, Dewulf, Maxime, Kalmar, Alain, Muysoms, Filip, Pletinckx, Pieter, Vandenberk, Bert   +6 more
core   +2 more sources

Diagnostic Value of Plasma Long Non-coding SLC26A4 Antisense RNA 1 Combined with Magnetic Resonance Imaging in Rectal Cancer

The Turkish Journal of Gastroenterology
Background/Aims: The prevalence of rectal cancer is increasing every year due to changes in living and eating habits. Early diagnosis contributes to the treatment and survival of patients.
Zhiqian Li, Mei Pu, Peng Zhou, Tao Zhang, Yang Xu, Yusui Zhang   +5 more
doaj   +1 more source

ggalign: Bridging the Grammar of Graphics and Biological Multilayered Complexity

Advanced Science, EarlyView.
The ggalign package provides a comprehensive framework for composable visualization built on top of ggplot2. Its primary purpose is to enable the construction of complex multi‐plot layouts with consistent observation alignment across plots, particularly for high‐dimensional data contexts such as genomics, transcriptomics, and microbiome studies ...
Yun Peng, Shan Jiang, Yuxuan Song, Peng Luo, Jianfeng Li, Dehua Hu, Jian‐Guo Zhou, Guangchuang Yu, Tao Xu, Shixiang Wang   +9 more
wiley   +1 more source