Results 121 to 130 of about 4,845,209 (387)

Ubiquitination‐Dependent LLGL2 Degradation Drives Colorectal Cancer Progression via THBS3 mRNA Stabilization

Advanced Science, EarlyView.
During the progression of CRC, MDM2, as an E3 ubiquitin ligase, promotes the degradation of the LLGL2 protein. Reduced expression of the LLGL2 protein leads to the loss of support for the CNOT1 protein, decreasing the degradation of THBS3 mRNA. The increased THBS3 further activates the PI3K‐Akt pathway, promoting the proliferation and metastasis of CRC.
Jiayan Huang, Tiantian Zhang, Huimin Li, Zidan Li, Shuangshuang Yin, Yiman Liu, Chunze Zhang, Yuling Qiu, Haiyang Yu   +8 more
wiley   +1 more source

Diagnostic Value of Plasma Long Non-coding SLC26A4 Antisense RNA 1 Combined with Magnetic Resonance Imaging in Rectal Cancer

The Turkish Journal of Gastroenterology
Background/Aims: The prevalence of rectal cancer is increasing every year due to changes in living and eating habits. Early diagnosis contributes to the treatment and survival of patients.
Zhiqian Li, Mei Pu, Peng Zhou, Tao Zhang, Yang Xu, Yusui Zhang   +5 more
doaj   +1 more source

Rectal cancer patients younger than 50 years lack a survival benefit from NCCN guideline–directed treatment for stage II and III disease

Cancer, 2018
The incidence of rectal cancer in patients younger than 50 years is increasing. To test the hypothesis that the biology in this younger cohort may differ, this study compared survival patterns, stratifying patients according to National Comprehensive ...
A. Kolarich, T. George, S. Hughes, D. Delitto, C. Allegra, W. Hall, G. Chang, Sanda A. Tan, Christiana M. Shaw, A. Iqbal   +9 more
semanticscholar   +1 more source

Loss of STARD7 Triggers Metabolic Reprogramming and Cell Cycle Arrest in Breast Cancer

Advanced Science, EarlyView.
Breast cancer cells undergo metabolic and transcriptomic reprogramming to support aberrant cell proliferation. Their mitochondria rely on the transfer of phosphatidylcholine from the endoplasmic reticulum to their membranes by STARD7, a candidate upregulated in breast cancer, to be functional.
Ewelina Dondajewska, Paula Allepuz‐Fuster, Chloé Maurizy, Alexandre Hego, Sandra Ormenese, Quentin Lion, Arnaud Blomme, Pierre Close, Arnaud Lavergne, Latifa Karim, Marc Thiry, Ivan Nemazanyy, Roopesh Krishnankutty, Jair Marques Jr, Alex von Kriegsheim, Nathaniel F. Henneman, Ganna Panasyuk, Kateryna Shostak, Alain Chariot   +18 more
wiley   +1 more source

A Population-Based Study of Secondary Prostate Cancer Risk after Radiotherapy in Male Patients with Rectal Cancer: A Retrospective Cohort Study

Medicina, 2019
Background and objective: Risk of secondary prostate cancer after radiation therapy among patients with rectal cancer remains undetermined. Given an increased incidence of rectal cancer in younger people and improved survival for rectal cancer patients ...
Jen-Pin Chuang, Yen-Chien Lee, Jenq-Chang Lee, Chin-Li Lu, Chung-Yi Li   +4 more
doaj   +1 more source

A retrospective cohort study of the influence of lifestyle factors on survival of patients undergoing surgery for colorectal cancer. [PDF]

, 2017
Aim: Several modifiable and non-modifiable health related behaviours are associated with the incidence of Colorectal Cancer (CRC), but there is little research on their association with survival.
Anderson, Boyle, Campbell, Courneya, Courneya, Dignam, Haggar, Haydon, Holmes, Hubbard, Kuiper, Manceau, Martinez, Meyerhardt, Meyerhardt, Morrison, Oliphant, Shafique, Van Blarigan, Vartiainen, Vrieling, World Cancer Research Fund/American Institute for Cancer Research   +21 more
core   +1 more source

AI‐Driven Defecation Analysis by Smart Healthcare Toilet: Exploring Biometric Patterns and Eu‐Tenesmus

Advanced Science, EarlyView.
A healthcare toilet system is introduced to passively measure defecation behavior. Real‐time data on stool dropping duration, thickness, and a newly defined “eu‐tenesmus” interval show correlations with stool form and gender differences. Results from 45 defecation events reveal a promising method for comprehensive defecation analysis.
Zhiquan Song, TaeHyung Kwon, Jeung Lee, Daeyoun D. Won, Brian J. Lee, Hyuk Soon Choi, Joseph C. Liao, Walter G. Park, Irene Sonu, Stephan Rogalla, Michael J. Rosen, David L. Hu, Jonathan Kuang Ziyang, Sunny Hei Wong, Bong Hyun Jun, Soh Kim, Seung‐min Park   +16 more
wiley   +1 more source

Effect of Laparoscopic-Assisted Resection vs Open Resection of Stage II or III Rectal Cancer on Pathologic Outcomes: The ACOSOG Z6051 Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2015
IMPORTANCE Evidence about the efficacy of laparoscopic resection of rectal cancer is incomplete, particularly for patients with more advanced-stage disease.
J. Fleshman, M. Branda, D. Sargent, A. Boller, Virgilio V George, M. Abbas, W. Peters, Dipen C. Maun, G. Chang, A. Herline, A. Fichera, Matthew G Mutch, S. Wexner, Mark H. Whiteford, John H. Marks, Elisa Birnbaum, D. Margolin, D. Larson, P. Marcello, M. Posner, T. Read, John Monson, S. Wren, P. Pisters, H. Nelson   +24 more
semanticscholar   +1 more source

STK25 Loss Augments Anti‐PD‐1 Therapy Efficacy by Regulating PD‐L1 Stability in Colorectal Cancer

Advanced Science, EarlyView.
This study demonstrates that STK25 depletion facilitates CRC immune escape through the inhibition of PD‐L1 Ser283 phosphorylation‐mediated ubiquitination, and promotes tumor growth. Furthermore, these findings identify STK25 as a potential therapeutic target to trigger antitumor immunity and promote immunotherapy efficacy. Abstract Tumor immune evasion
Xiaowen Qiao, Pu Xing, Hao Hao, Jiangbo Chen, Lin Song, Yifan Hou, Xinying Yang, Kai Weng, Jie Chen, Pin Gao, Tongkun Song, Hong Yang, Tianqi Liu, Yumeng Ran, Bo Chen, Wei Zhao, Jiabo Di, Zaozao Wang, Jun Zhang, Xiangqian Su, Beihai Jiang   +20 more
wiley   +1 more source

TCF7 transcriptional activation of MACC1 regulates aerobic glycolysis and promotes oxaliplatin resistance in rectal cancer [PDF]

Zhongguo aizheng zazhi
Background and purpose: Rectal cancer occurs on the inner wall of the rectum, and metastasis-associated in colon cancer 1 (MACC1) can promote drug resistance in colon cancer cells.
YAN Yan, ZHOU Liqing, XIA Jianhong, MA Tingting
doaj   +1 more source