Results 101 to 110 of about 5,235,363 (361)

Clinical significance of Neutrophil gelatinase-associated lipocalin(NGAL) expression in primary rectal cancer

BMC Cancer, 2009
Background Emerging evidence has demonstrated that Neutrophil gelatinase-associated lipocalin (NGAL) is up-regulated in multiple malignancies, including oesophagus cancer, and plays a critical role in tumorigenesis and progression.
Guo Gui-Long, Wang Ou-Chen, Yang Guan-Gen, Zhou Su-Mei, Zhang Xiao-Hua, Zhang Ying, Zhang Xiu-Feng, Yang Gao-Yi, Hu Xiao-Qu   +8 more
doaj   +1 more source

ctDNA applications and integration in colorectal cancer: an NCI Colon and Rectal–Anal Task Forces whitepaper

Nature Reviews Clinical Oncology, 2020
An increasing number of studies are describing potential uses of circulating tumour DNA (ctDNA) in the care of patients with colorectal cancer. Owing to this rapidly developing area of research, the Colon and Rectal–Anal Task Forces of the United States ...
A. Dasari, V. Morris, C. Allegra, C. Atreya, A. Benson, P. Boland, Ki Chung, M. Copur, R. Corcoran, D. Deming, A. Dwyer, M. Diehn, C. Eng, T. George, M. Gollub, R. Goodwin, Stanley R. Hamilton, J. Hechtman, H. Hochster, T. Hong, F. Innocenti, A. Iqbal, S. Jacobs, H. Kennecke, James J. Lee, C. Lieu, H. Lenz, O. W. Lindwasser, C. Montagut, B. Odisio, F. Ou, Laura D. Porter, K. Raghav, D. Schrag, A. Scott, Q. Shi, J. Strickler, A. Venook, R. Yaeger, G. Yothers, Y. You, J. Zell, S. Kopetz   +42 more
semanticscholar   +1 more source

Epithelial TRIM27 Inhibits Intestinal Inflammation in Ulcerative Colitis by the USP7/TRIM27‐IKK Double Negative‐Feedback

Advanced Science, EarlyView.
ABSTRACT The E3 ubiquitin ligase tripartite motif 27 (TRIM27) is a negative regulator of NF‐κB activation and the innate immune response, and TRIM27 deficiency significantly impairs dextran sulfate sodium (DSS)‐induced colitis. The function of TRIM27 in intestinal epithelial cells (IECs), the mechanism by which TRIM27 inhibits the NF‐κB pathway and its
Weimin Xu, Zhebin Hua, Zhujiang Dai, Shasha Zhang, Yihan Jiang, Wensong Ge, YingWei Chen, Zhongchuan Wang, Bing Zhang, Chen‐Ying Liu, Peng Du   +10 more
wiley   +1 more source

Reducing DCO registrations through electronic matching of cancer registry data and routine hospital data [PDF]

, 2000
From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License.
N Vickers, Pollock, AM, A M Pollock, Vickers, N   +3 more
core   +1 more source

The Development and Pilot Clinical Study of CD147 Targeted Antagonistic Peptide Probe for Tumor Imaging

Advanced Science, EarlyView.
This study establishes [68Ga]Ga‐DOTA‐AP9 as a first‐in‐human CD147‐targeted PET tracer with favorable safety and specific tumor uptake. Tracer accumulation correlates with CD147 expression in patients, enabling noninvasive quantification of CD147‐positive malignancies.
Xiaokun Ma, Rui Guo, Dongfeng Niu, Yufei Song, Zhenyao Zhang, Xiangxi Meng, Lili Mao, Haifeng Huang, Hua Zhu, Zhi Yang, Teli Liu   +10 more
wiley   +1 more source

Patient delay in colorectal cancer patients: associations with rectal bleeding and thoughts about cancer.

PLoS ONE, 2013
Rectal bleeding is considered to be an alarm symptom of colorectal cancer. However, the symptom is seldom reported to the general practitioner and it is often assumed that patients assign the rectal bleeding to benign conditions.
Anette F Pedersen, Rikke P Hansen, Peter Vedsted   +2 more
doaj   +1 more source

Long-term Oncological and Functional Outcomes of Chemoradiotherapy Followed by Organ-Sparing Transanal Endoscopic Microsurgery for Distal Rectal Cancer: The CARTS Study

JAMA Surgery, 2019
Importance Treatment of rectal cancer is shifting toward organ preservation aiming to reduce surgery-related morbidity. Short-term outcomes of organ-preserving strategies are promising, but long-term outcomes are scarce in the literature.
Rutger C. H. Stijns, E. D. de Graaf, C. Punt, I. Nagtegaal, J. Nuyttens, E. van Meerten, P. Tanis, I. D. de Hingh, G. P. van der Schelling, Y. Acherman, J. Leijtens, A. Bremers, G. Beets, C. Hoff, C. Verhoef, C. Marijnen, J. D. de Wilt   +16 more
semanticscholar   +1 more source

Cost-effectiveness of preoperative radiotherapy in rectal cancer: results from the Swedish Rectal Cancer Trial

, 2002
PURPOSE: The Swedish Rectal Cancer Trial (SRCT) demonstrated that a short-term regimen of high-dose fractionated preoperative radiotherapy (5 x 5 Gy) reduced the local recurrence rates and improved overall survival.
Dahlberg, M, Stenborg, A, Swedish, Rectal Cancer Trial, Påhlman, L, Glimelius, B,   +4 more
core   +1 more source

TME/NIR Dual‐Responsive Zinc‐Based Targeted Nanoagonist for Multimodal Amplification of STING‐Mediated Cancer Immunotherapy

Advanced Science, EarlyView.
A multifunctional nanoagonist (cDZ@IP) enables nano‐metabolite–driven multimodal activation of the STING pathway and enhanced immune recognition, achieving potent antitumor immunity and suppressing tumor growth and metastasis. This strategy highlights the rational design of therapeutic metabolites and establishes a new paradigm bridging nanomedicine ...
Kepeng Hu, Jiawei Wang, Wei Zhang, Zhixuan Wu, Jing Chen, Yujing He, Xiyue Duan, Yaoting He, Xin Xin, Haoyi Xiang, Yijing Wang, Chengwei Wu, Yang Yi, Qing Meng, Yuqian Qiao, Kui Cheng, Xiaojun Long, Zhangfa Song   +17 more
wiley   +1 more source

Laparoscopic low anterior resection for rectal cancer with rectal prolapse: a case report

Journal of Medical Case Reports, 2018
Background Rectal cancer with rectal prolapse is rare, described by only a few case reports. Recently, laparoscopic surgery has become standard procedure for either rectal cancer or rectal prolapse. However, the use of laparoscopic low anterior resection
Ryusei Yamamoto, Yasuji Mokuno, Hideo Matsubara, Hirokazu Kaneko, Shinsuke Iyomasa   +4 more
doaj   +1 more source