Results 91 to 100 of about 3,176,177 (307)

Tissue-associated bacterial alterations in rectal carcinoma patients revealed by 16S rRNA community profiling

Frontiers in Cellular and Infection Microbiology, 2016
Sporadic and inflammatory forms of colorectal cancer (CRC) account for more than 80% of cases. Recent publications have shown mechanistic evidence for the involvement of gut bacteria in the development of both CRC-forms.
Andrew Maltez Thomas, Andrew Maltez Thomas, Andrew Maltez Thomas, Eliane Camargo de Jesus, Eliane Camargo de Jesus, Ademar Lopes, Samuel Aguiar Junior, Maria Dirlei Begnami, Rafael Malagoli Rocha, Paola Avelar Carpinetti, Anamaria Aranha Camargo, Christian Hoffmann, Helano Carioca Freitas, Helano Carioca Freitas, Israel Tojal da Silva, Diana Noronha Nunes, Joao Carlos Setubal, Joao Carlos Setubal, Emmanuel Dias-Neto, Emmanuel Dias-Neto   +19 more
doaj   +1 more source

Cost-effectiveness of preoperative radiotherapy in rectal cancer: results from the Swedish Rectal Cancer Trial

, 2002
PURPOSE: The Swedish Rectal Cancer Trial (SRCT) demonstrated that a short-term regimen of high-dose fractionated preoperative radiotherapy (5 x 5 Gy) reduced the local recurrence rates and improved overall survival.
Dahlberg, M, Stenborg, A, Swedish, Rectal Cancer Trial, Påhlman, L, Glimelius, B,   +4 more
core   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Constructing a personalized nomogram model for predicting anastomotic leakage after laparoscopic radical resection of rectal cancer

Journal of Radiation Research and Applied Sciences
The purpose of this study was to explore the risk factors for anastomotic leakage (AL) after laparoscopic radical resection of rectal cancer and to construct a nomogram prediction model for AL after laparoscopic radical resection of rectal cancer.
Caigui Liu, Shikang Xu, Yunxiang Zhu, Xiuxiu Cai   +3 more
doaj   +1 more source

Long-Term Stoma-Free Outcomes After Diverting Stoma Closure Following Radiation-Based Neoadjuvant Treatment for Rectal Cancer. [PDF]

Ann Gastroenterol Surg
ABSTRACT Aim Long‐term stoma‐free outcomes after diverting stoma closure in patients who underwent sphincter‐preserving rectal cancer surgery with double‐stapling technique (DST) reconstruction following radiation‐based neoadjuvant treatment remain unclear.
Ichikawa H, Matsui S, Sato K, Noguchi T, Sakamoto T, Mukai T, Yamaguchi T, Akiyoshi T.   +7 more
europepmc   +2 more sources

Rectal Cancer [PDF]

Clinics in Colon and Rectal Surgery, 2015
James W, Fleshman, Warren E, Lichliter
openaire   +2 more sources

Oral Nanomicelle‐Mediated Sequential Butyrate Production in the Intestine for Ulcerative Colitis and Immunosuppression Treatment

Advanced Science, EarlyView.
After oral administration, inodorous GLU‐BA self‐assembles into nanomicelles in aqueous environments to resist premature gastric adsorption. Upon reaching the intestine, endogenous esterases rapidly cleave the built‐in ester bonds in these nanomicelles to release BA and GLU, with GLU further metabolized by gut microbiota to gradually generate BA ...
Feifei Xin, Zhike Xie, Danyue Zhao, Lin Yang, Yiqun Wan, Zuwei Liu, Situ Xiong, Ying Zhang, Lei Feng, Hao Wan   +9 more
wiley   +1 more source

A Population-Based Study of Secondary Prostate Cancer Risk after Radiotherapy in Male Patients with Rectal Cancer: A Retrospective Cohort Study

Medicina, 2019
Background and objective: Risk of secondary prostate cancer after radiation therapy among patients with rectal cancer remains undetermined. Given an increased incidence of rectal cancer in younger people and improved survival for rectal cancer patients ...
Jen-Pin Chuang, Yen-Chien Lee, Jenq-Chang Lee, Chin-Li Lu, Chung-Yi Li   +4 more
doaj   +1 more source

Discovery and Optimization of AMT‐676, a CDH17‐Targeting ADC for the Treatment of Advanced Gastrointestinal Cancers

Advanced Science, EarlyView.
AMT‐676 is a novel antibody‐drug conjugate targeting CDH17, an adhesion molecule uniquely exposed on gastrointestinal tumor surfaces. Engineered with an optimized exatecan payload, it demonstrates profound tumor regression and a robust bystander effect across diverse preclinical models.
Ying‐nan Wang, Dan‐yun Ruan, Jing Shi, Yue Huang, Hui Sheng, Ya‐ling Huang, Linjie Ma, Lijun Wang, Caiwei Chen, Yixuan Wang, Yue Zhang, Yi Shen, Qing Zhang, Jianjian Zhang, Yanfang Tang, Jin‐ling Zhang, Jia‐jia Hu, Chen‐yi Wu, Jia‐ying Chen, Xun Meng, Shu‐Hui Liu, Feng Wang   +21 more
wiley   +1 more source

European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender

BJS (British Journal of Surgery), EarlyView., 2020
Recommendations for clinical and molecular identification of LS, surgical and endoscopic management of LS‐associated colorectal cancer and preventive measures for cancer were produced. The emphasis was on surgical and gastroenterological aspects of the cancer spectrum.
T. T. Seppälä, A. Latchford, I. Negoi, A. Sampaio Soares, R. Jimenez‐Rodriguez, L. Sánchez‐Guillén, D. G. Evans, N. Ryan, E. J. Crosbie, M. Dominguez‐Valentin, J. Burn, M. Kloor, M. von Knebel Doeberitz, F. J. B. van Duijnhoven, P. Quirke, J. R. Sampson, P. Møller, G. Möslein, on behalf of the European Hereditary Tumour Group (EHTG) and European Society of Coloproctology (ESCP)   +18 more
wiley   +1 more source